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rdf:type |
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lifeskim:mentions |
umls-concept:C0033268,
umls-concept:C0039194,
umls-concept:C0085358,
umls-concept:C1280500,
umls-concept:C1332714,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1420610,
umls-concept:C1423842,
umls-concept:C1706438,
umls-concept:C1881379,
umls-concept:C2698600
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pubmed:issue |
5553
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pubmed:dateCreated |
2002-1-11
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pubmed:abstractText |
T-bet is a member of the T-box family of transcription factors that appears to regulate lineage commitment in CD4 T helper (TH) lymphocytes in part by activating the hallmark TH1 cytokine, interferon-gamma (IFN-gamma). IFN-gamma is also produced by natural killer (NK) cells and most prominently by CD8 cytotoxic T cells, and is vital for the control of microbial pathogens. Although T-bet is expressed in all these cell types, it is required for control of IFN-gamma production in CD4 and NK cells, but not in CD8 cells. This difference is also apparent in the function of these cell subsets. Thus, the regulation of a single cytokine, IFN-gamma, is controlled by distinct transcriptional mechanisms within the T cell lineage.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1095-9203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
11
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pubmed:volume |
295
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
338-42
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11786644-Animals,
pubmed-meshheading:11786644-CD4-Positive T-Lymphocytes,
pubmed-meshheading:11786644-Cell Differentiation,
pubmed-meshheading:11786644-Cell Line,
pubmed-meshheading:11786644-Cell Lineage,
pubmed-meshheading:11786644-Cytotoxicity, Immunologic,
pubmed-meshheading:11786644-Gene Targeting,
pubmed-meshheading:11786644-Immunization,
pubmed-meshheading:11786644-Immunoglobulin G,
pubmed-meshheading:11786644-Interferon-gamma,
pubmed-meshheading:11786644-Interleukin-4,
pubmed-meshheading:11786644-Interleukin-5,
pubmed-meshheading:11786644-Killer Cells, Natural,
pubmed-meshheading:11786644-Leishmania major,
pubmed-meshheading:11786644-Leishmaniasis, Cutaneous,
pubmed-meshheading:11786644-Mice,
pubmed-meshheading:11786644-Mice, Inbred BALB C,
pubmed-meshheading:11786644-Mice, Inbred C57BL,
pubmed-meshheading:11786644-T-Box Domain Proteins,
pubmed-meshheading:11786644-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:11786644-Th1 Cells,
pubmed-meshheading:11786644-Transcription Factors
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pubmed:year |
2002
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pubmed:articleTitle |
Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells.
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pubmed:affiliation |
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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