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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2002-1-8
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pubmed:abstractText |
Systemic mycosis is among the most feared opportunistic infections in the immunocompromised host. Difficulty and delay in diagnosis and treatment often result in poor outcomes. In this communication a metastatically spreading form of subcutaneous aspergillosis developed in a patient with a history of allogeneic stem cell transplantation for relapsed Hodgkin's lymphoma. Strikingly, necrotizing cutaneous papules or ulcerating lesions were absent. Diagnosis was accomplished after excision of a clinically non-suggestive subcutaneous nodule. Despite prompt initiation of antimycotic therapy the outcome was fatal; dosage of conventional and liposomal amphotericin B was limited due to treatment-related toxicities. This case report describes a novel form of aspergillosis and underlines the need for an aggressive diagnostic approach in severely immunocompromised patients.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amphotericin B,
http://linkedlifedata.com/resource/pubmed/chemical/Antifungal Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Bleomycin,
http://linkedlifedata.com/resource/pubmed/chemical/Carmustine,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclophosphamide,
http://linkedlifedata.com/resource/pubmed/chemical/Cytarabine,
http://linkedlifedata.com/resource/pubmed/chemical/Dacarbazine,
http://linkedlifedata.com/resource/pubmed/chemical/Deoxycytidine,
http://linkedlifedata.com/resource/pubmed/chemical/Dexamethasone,
http://linkedlifedata.com/resource/pubmed/chemical/Doxorubicin,
http://linkedlifedata.com/resource/pubmed/chemical/Etoposide,
http://linkedlifedata.com/resource/pubmed/chemical/Melphalan,
http://linkedlifedata.com/resource/pubmed/chemical/Prednisone,
http://linkedlifedata.com/resource/pubmed/chemical/Procarbazine,
http://linkedlifedata.com/resource/pubmed/chemical/Vinblastine,
http://linkedlifedata.com/resource/pubmed/chemical/Vincristine,
http://linkedlifedata.com/resource/pubmed/chemical/gemcitabine
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0268-3369
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
28
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
899-901
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pubmed:dateRevised |
2006-4-24
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pubmed:meshHeading |
pubmed-meshheading:11781653-Adult,
pubmed-meshheading:11781653-Amphotericin B,
pubmed-meshheading:11781653-Antifungal Agents,
pubmed-meshheading:11781653-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:11781653-Aspergillosis,
pubmed-meshheading:11781653-Bleomycin,
pubmed-meshheading:11781653-Carmustine,
pubmed-meshheading:11781653-Combined Modality Therapy,
pubmed-meshheading:11781653-Cyclophosphamide,
pubmed-meshheading:11781653-Cytarabine,
pubmed-meshheading:11781653-Dacarbazine,
pubmed-meshheading:11781653-Deoxycytidine,
pubmed-meshheading:11781653-Dexamethasone,
pubmed-meshheading:11781653-Doxorubicin,
pubmed-meshheading:11781653-Etoposide,
pubmed-meshheading:11781653-Fatal Outcome,
pubmed-meshheading:11781653-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:11781653-Hodgkin Disease,
pubmed-meshheading:11781653-Humans,
pubmed-meshheading:11781653-Immunocompromised Host,
pubmed-meshheading:11781653-Klebsiella Infections,
pubmed-meshheading:11781653-Klebsiella pneumoniae,
pubmed-meshheading:11781653-Lung Diseases, Fungal,
pubmed-meshheading:11781653-Male,
pubmed-meshheading:11781653-Melphalan,
pubmed-meshheading:11781653-Neoplasm Recurrence, Local,
pubmed-meshheading:11781653-Opportunistic Infections,
pubmed-meshheading:11781653-Pneumonia, Bacterial,
pubmed-meshheading:11781653-Pneumonia, Pneumocystis,
pubmed-meshheading:11781653-Prednisone,
pubmed-meshheading:11781653-Procarbazine,
pubmed-meshheading:11781653-Salvage Therapy,
pubmed-meshheading:11781653-Skin,
pubmed-meshheading:11781653-Transplantation, Homologous,
pubmed-meshheading:11781653-Vinblastine,
pubmed-meshheading:11781653-Vincristine
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pubmed:year |
2001
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pubmed:articleTitle |
A novel type of metastatically spreading subcutaneous aspergillosis without epidermal lesions following allogeneic stem cell transplantation.
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pubmed:affiliation |
Department I of Internal Medicine, Hematology, Oncology and Infectious Diseases, University of Cologne, Cologne, Germany.
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pubmed:publicationType |
Journal Article,
Case Reports
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