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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2002-1-8
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pubmed:abstractText |
Effector and memory T cells can be subdivided based on their ability to traffic through peripheral tissues such as inflamed skin and intestinal lamina propria, a property controlled by expression of 'tissue-specific' adhesion and chemoattractant receptors. However, little is known about the development of these selectively homing T cell subsets, and it is unclear whether activation in cutaneous versus intestinal lymphoid organs directly results in effector/memory T cells that differentially express adhesion and chemoattractant receptors targeting them to the corresponding nonlymphoid site. We define two murine CD4(+) effector/memory T cell subsets that preferentially localize in cutaneous or intestinal lymphoid organs by their reciprocal expression of the adhesion molecules P-selectin ligand (P-lig) and alpha 4 beta 7, respectively. We show that within 2 d of systemic immunization CD4(+) T cells activated in cutaneous lymph nodes upregulate P-lig, and downregulate alpha 4 beta 7, while those responding to antigen in intestinal lymph nodes selectively express high levels of alpha 4 beta 7 and acquire responsiveness to the intestinal chemokine thymus-expressed chemokine (TECK). Thus, during an immune response, local microenvironments within cutaneous and intestinal secondary lymphoid organs differentially direct T cell expression of these adhesion and chemoattractant receptors, targeting the resulting effector T cells to the inflamed skin or intestinal lamina propria.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781372-10227989,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781372-10361577,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781372-10544196,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781372-10974041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781372-11123282,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781372-1955763,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781372-2139106,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781372-4187528,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781372-6985693,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781372-7542550,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781372-7678617,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781372-7722470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781372-7889419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781372-844479,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781372-8600538,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781372-8621908,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781372-8985251,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781372-9060447,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781372-9190904,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781372-9276738,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781372-9295049,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781372-9529145,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781372-9550400,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781372-9585422,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781372-9670976,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781372-9834120,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781372-9885220
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
7
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pubmed:volume |
195
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
135-41
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:11781372-Animals,
pubmed-meshheading:11781372-CD4-Positive T-Lymphocytes,
pubmed-meshheading:11781372-Cell Adhesion,
pubmed-meshheading:11781372-Chemotaxis, Leukocyte,
pubmed-meshheading:11781372-Immunologic Memory,
pubmed-meshheading:11781372-Integrins,
pubmed-meshheading:11781372-Intestinal Mucosa,
pubmed-meshheading:11781372-Lymphocyte Activation,
pubmed-meshheading:11781372-Lymphoid Tissue,
pubmed-meshheading:11781372-Membrane Glycoproteins,
pubmed-meshheading:11781372-Mice,
pubmed-meshheading:11781372-Mice, Inbred BALB C,
pubmed-meshheading:11781372-Skin,
pubmed-meshheading:11781372-T-Lymphocyte Subsets
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pubmed:year |
2002
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pubmed:articleTitle |
Rapid acquisition of tissue-specific homing phenotypes by CD4(+) T cells activated in cutaneous or mucosal lymphoid tissues.
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pubmed:affiliation |
Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA. daniel@macampbell.com
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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