| pubmed-article:11781354 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11781354 | lifeskim:mentions | umls-concept:C1519718 | lld:lifeskim |
| pubmed-article:11781354 | lifeskim:mentions | umls-concept:C0001128 | lld:lifeskim |
| pubmed-article:11781354 | lifeskim:mentions | umls-concept:C0596902 | lld:lifeskim |
| pubmed-article:11781354 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:11781354 | lifeskim:mentions | umls-concept:C1555029 | lld:lifeskim |
| pubmed-article:11781354 | lifeskim:mentions | umls-concept:C0596963 | lld:lifeskim |
| pubmed-article:11781354 | lifeskim:mentions | umls-concept:C1979572 | lld:lifeskim |
| pubmed-article:11781354 | lifeskim:mentions | umls-concept:C1980044 | lld:lifeskim |
| pubmed-article:11781354 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
| pubmed-article:11781354 | lifeskim:mentions | umls-concept:C0525695 | lld:lifeskim |
| pubmed-article:11781354 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:11781354 | pubmed:dateCreated | 2002-1-8 | lld:pubmed |
| pubmed-article:11781354 | pubmed:abstractText | Metabolic acidosis causes a reversal of polarity of HCO(3)(-) flux in the cortical collecting duct (CCD). In CCDs incubated in vitro in acid media, beta-intercalated (HCO(3)(-)-secreting) cells are remodeled to functionally resemble alpha-intercalated (H(+)-secreting) cells. A similar remodeling of beta-intercalated cells, in which the polarity of H(+) pumps and Cl(-)/HCO(3)(-) exchangers is reversed, occurs in cell culture and requires the deposition of polymerized hensin in the ECM. CCDs maintained 3 h at low pH ex vivo display a reversal of HCO(3)(-) flux that is quantitatively similar to an effect previously observed in acid-treated rabbits in vivo. We followed intracellular pH in the same beta-intercalated cells before and after acid incubation and found that apical Cl/HCO(3) exchange was abolished following acid incubation. Some cells also developed basolateral Cl(-)/HCO(3)(-) exchange, indicating a reversal of intercalated cell polarity. This adaptation required intact microtubules and microfilaments, as well as new protein synthesis, and was associated with decreased size of the apical surface of beta-intercalated cells. Addition of anti-hensin antibodies prevented the acid-induced changes in apical and basolateral Cl(-)/HCO(3)(-) exchange observed in the same cells and the corresponding suppression of HCO(3)(-) secretion. Acid loading also promoted hensin deposition in the ECM underneath adapting beta-intercalated cells. Hence, the adaptive conversion of beta-intercalated cells to alpha-intercalated cells during acid incubation depends upon ECM-associated hensin. | lld:pubmed |
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| pubmed-article:11781354 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11781354 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11781354 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:11781354 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11781354 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:11781354 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:11781354 | pubmed:author | pubmed-author:PetrovicSneza... | lld:pubmed |
| pubmed-article:11781354 | pubmed:author | pubmed-author:TsuruokaShuic... | lld:pubmed |
| pubmed-article:11781354 | pubmed:author | pubmed-author:SchwartzGeorg... | lld:pubmed |
| pubmed-article:11781354 | pubmed:author | pubmed-author:VijayakumarSo... | lld:pubmed |
| pubmed-article:11781354 | pubmed:author | pubmed-author:MianAyesaA | lld:pubmed |
| pubmed-article:11781354 | pubmed:author | pubmed-author:Al-AwqatiQais... | lld:pubmed |
| pubmed-article:11781354 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11781354 | pubmed:volume | 109 | lld:pubmed |
| pubmed-article:11781354 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11781354 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11781354 | pubmed:pagination | 89-99 | lld:pubmed |
| pubmed-article:11781354 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:11781354 | pubmed:year | 2002 | lld:pubmed |
