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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2002-1-7
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pubmed:abstractText |
The unfolded protein response (UPR) is a transcriptional and translational intracellular signaling pathway activated by the accumulation of unfolded proteins in the lumen of the endoplasmic reticulum (ER). We have used C. elegans as a genetic model system to dissect UPR signaling in a multicellular organism. C. elegans requires ire-1-mediated splicing of xbp-1 mRNA for UPR gene transcription and survival upon ER stress. In addition, ire-1/xbp-1 acts with pek-1, a protein kinase that mediates translation attenuation, in complementary pathways that are essential for worm development and survival. We propose that UPR transcriptional activation by ire-1 as well as translational attenuation by pek-1 maintain ER homeostasis. The results demonstrate that the UPR and ER homeostasis are essential for metazoan development.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Caenorhabditis elegans Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Fungal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/IRE1 protein, S cerevisiae,
http://linkedlifedata.com/resource/pubmed/chemical/MAP Kinase Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase...,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Saccharomyces cerevisiae Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/XBP1 protein, S cerevisiae
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0092-8674
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pubmed:author |
pubmed-author:EllisR ERE,
pubmed-author:KaufmanR JRJ,
pubmed-author:KurnitD MDM,
pubmed-author:LeeKK,
pubmed-author:LiuC YCY,
pubmed-author:MoriKK,
pubmed-author:MorimotoRR,
pubmed-author:SheaWW,
pubmed-author:SolomonAA,
pubmed-author:YanoCC,
pubmed-author:YoshidaHH
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pubmed:issnType |
Print
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pubmed:day |
28
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pubmed:volume |
107
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
893-903
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11779465-Animals,
pubmed-meshheading:11779465-Caenorhabditis elegans,
pubmed-meshheading:11779465-Caenorhabditis elegans Proteins,
pubmed-meshheading:11779465-Cell Cycle Proteins,
pubmed-meshheading:11779465-Fungal Proteins,
pubmed-meshheading:11779465-MAP Kinase Kinase 1,
pubmed-meshheading:11779465-Membrane Glycoproteins,
pubmed-meshheading:11779465-Mitogen-Activated Protein Kinase Kinases,
pubmed-meshheading:11779465-Molecular Sequence Data,
pubmed-meshheading:11779465-Mutation,
pubmed-meshheading:11779465-Protein Folding,
pubmed-meshheading:11779465-Protein-Serine-Threonine Kinases,
pubmed-meshheading:11779465-Repressor Proteins,
pubmed-meshheading:11779465-Saccharomyces cerevisiae Proteins,
pubmed-meshheading:11779465-Signal Transduction,
pubmed-meshheading:11779465-Transcription Factors,
pubmed-meshheading:11779465-Transcriptional Activation
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pubmed:year |
2001
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pubmed:articleTitle |
Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development.
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pubmed:affiliation |
Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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