rdf:type |
|
lifeskim:mentions |
umls-concept:C0033684,
umls-concept:C0042567,
umls-concept:C0205314,
umls-concept:C0259902,
umls-concept:C0679622,
umls-concept:C0851285,
umls-concept:C1334043,
umls-concept:C1412517,
umls-concept:C1423613,
umls-concept:C1425340,
umls-concept:C1546857,
umls-concept:C1720675,
umls-concept:C1879547,
umls-concept:C2697616
|
pubmed:issue |
7
|
pubmed:dateCreated |
2002-1-7
|
pubmed:abstractText |
Wnt signaling via the Frizzled (Fz) receptor controls cell polarity and movement during development, but the molecular nature of Wnt/Fz polarity signal transduction remains poorly defined. Here we report that in human cells and during Xenopus embryogenesis, Wnt/Fz signaling activates the small GTPase Rho, a key regulator of cytoskeleton architecture. Wnt/Fz activation of Rho requires the cytoplasmic protein Dishevelled (Dvl) and a novel Formin homology protein Daam1. Daam1 binds to both Dvl and Rho, and mediates Wnt-induced Dvl-Rho complex formation. Inhibition or depletion of Daam1 prevents Wnt/Fz activation of Rho and of Xenopus gastrulation, but not of beta-catenin signaling. Our study illustrates a molecular pathway from Wnt/Fz signaling to Rho activation in cell polarity signal transduction.
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pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Frizzled Receptors,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Xenopus Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Zebrafish Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/rho GTP-Binding Proteins
|
pubmed:status |
MEDLINE
|
pubmed:month |
Dec
|
pubmed:issn |
0092-8674
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
28
|
pubmed:volume |
107
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
843-54
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:11779461-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:11779461-Animals,
pubmed-meshheading:11779461-Carrier Proteins,
pubmed-meshheading:11779461-Cell Polarity,
pubmed-meshheading:11779461-Embryo, Nonmammalian,
pubmed-meshheading:11779461-Frizzled Receptors,
pubmed-meshheading:11779461-Gastrula,
pubmed-meshheading:11779461-Humans,
pubmed-meshheading:11779461-Nuclear Proteins,
pubmed-meshheading:11779461-Proteins,
pubmed-meshheading:11779461-Proto-Oncogene Proteins,
pubmed-meshheading:11779461-Signal Transduction,
pubmed-meshheading:11779461-Wnt Proteins,
pubmed-meshheading:11779461-Xenopus,
pubmed-meshheading:11779461-Xenopus Proteins,
pubmed-meshheading:11779461-Zebrafish Proteins,
pubmed-meshheading:11779461-rho GTP-Binding Proteins
|
pubmed:year |
2001
|
pubmed:articleTitle |
Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1.
|
pubmed:affiliation |
Division of Neuroscience, Children's Hospital, Department of Neurology, Harvard Medical School, Boston, MA 02115, USA.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|