Source:http://linkedlifedata.com/resource/pubmed/id/11779195
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2002-1-7
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| pubmed:abstractText |
Hepatocyte growth factor (HGF) plays a crucial role in the recovery of injured liver. Liver functions are mostly impaired in patients with liver diseases including cirrhosis. However, a significant amount of inactive HGF precursor (proHGF) is reported in the plasma of these patients. proHGF is proteolytically converted to an active form (mature HGF) by HGF-activator. Thus conversion of proHGF into mature HGF presumably contributes to the recovery of liver functions. In this study, rats with a partial hepatectomy were used, as proHGF is accumulated in the remnant liver. Recombinant human HGF-activator was administered via the portal vein to investigate the effect on molecular forms of HGF and its biological signaling. rhHGF-activator promptly converted proHGF into mature HGF, reaching maximal levels at 5-10 min after the injection, while the decreased proHGF was quickly recovered to the initial levels in the liver. The HGF receptor/c-Met was found to be autophosphorylated in the liver treated with rhHGF-activator. Further, the proliferating cell nuclear antigen labeling index and the liver regeneration rate were significantly higher in rhHGF-activator group than in control animals. These results indicate that exogenously administered HGF-activator produces a biologically active HGF from its precursor form and increases the potential for liver regeneration in vivo.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/HGF activator,
http://linkedlifedata.com/resource/pubmed/chemical/Hepatocyte Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Proliferating Cell Nuclear Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Serine Endopeptidases
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
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| pubmed:issn |
0006-291X
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| pubmed:author | |
| pubmed:copyrightInfo |
(c)2002 Elsevier Science.
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| pubmed:issnType |
Print
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| pubmed:day |
11
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| pubmed:volume |
290
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
475-81
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11779195-Animals,
pubmed-meshheading:11779195-Blotting, Western,
pubmed-meshheading:11779195-Cell Division,
pubmed-meshheading:11779195-DNA, Complementary,
pubmed-meshheading:11779195-Dose-Response Relationship, Drug,
pubmed-meshheading:11779195-Hepatectomy,
pubmed-meshheading:11779195-Hepatocyte Growth Factor,
pubmed-meshheading:11779195-Humans,
pubmed-meshheading:11779195-Liver,
pubmed-meshheading:11779195-Phosphorylation,
pubmed-meshheading:11779195-Precipitin Tests,
pubmed-meshheading:11779195-Proliferating Cell Nuclear Antigen,
pubmed-meshheading:11779195-Rats,
pubmed-meshheading:11779195-Rats, Sprague-Dawley,
pubmed-meshheading:11779195-Recombinant Proteins,
pubmed-meshheading:11779195-Regeneration,
pubmed-meshheading:11779195-Serine Endopeptidases,
pubmed-meshheading:11779195-Signal Transduction,
pubmed-meshheading:11779195-Time Factors
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| pubmed:year |
2002
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| pubmed:articleTitle |
Exogenously administered HGF activator augments liver regeneration through the production of biologically active HGF.
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| pubmed:affiliation |
First Department of Surgery, Kansai Medical University, 10-15 Fumisonocho, Moriguchi, Osaka 570-8506, Japan.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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