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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2002-1-4
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pubmed:abstractText |
We analyzed the HLA class II haplotypes in 249 Finnish nuclear families and compared the frequencies of parental haplotypes transmitted or non-transmitted to multiple sclerosis (MS) patients. The most important predisposing haplotype was DRB1*15-DQB1*0602 (P<10(-6)) as expected and a weak predisposing effect of DRB1*04-DQB1*0302 was revealed after the elimination of DRB1*15-DQB1*0602. HLA-DRB1*01-DQB1*0501 and DRB1*13-DQB1*0603 were negatively associated with MS in transmission disequilibrium test, but only the DRB1*13-DQB1*0603 association remained significant (P=0.008) after the elimination of DRB1*15-DQB1*0602 haplotypes. Based on this study HLA class II haplotypes exhibit both predisposing and protective effects in MS.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0165-5728
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pubmed:author |
pubmed-author:IlonenJormaJ,
pubmed-author:KuokkanenSatuS,
pubmed-author:LaaksonenMikkoM,
pubmed-author:PaneliusMartinM,
pubmed-author:PartanenJukkaJ,
pubmed-author:PastinenTomiT,
pubmed-author:ReijonenHelenaH,
pubmed-author:RuutiainenJuhaniJ,
pubmed-author:SalonenReijoR,
pubmed-author:SjöroosMinnaM,
pubmed-author:SumelahtiMarja LiisaML,
pubmed-author:TienariPentti JPJ,
pubmed-author:WikströmJuhaniJ
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pubmed:issnType |
Print
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pubmed:volume |
122
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
140-5
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:11777553-Family Health,
pubmed-meshheading:11777553-Finland,
pubmed-meshheading:11777553-Genetic Predisposition to Disease,
pubmed-meshheading:11777553-HLA-DQ Antigens,
pubmed-meshheading:11777553-HLA-DQ beta-Chains,
pubmed-meshheading:11777553-HLA-DR Antigens,
pubmed-meshheading:11777553-HLA-DRB1 Chains,
pubmed-meshheading:11777553-Histocompatibility Antigens Class II,
pubmed-meshheading:11777553-Histocompatibility Testing,
pubmed-meshheading:11777553-Humans,
pubmed-meshheading:11777553-Multiple Sclerosis,
pubmed-meshheading:11777553-Risk Factors
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pubmed:year |
2002
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pubmed:articleTitle |
HLA class II associated risk and protection against multiple sclerosis-a Finnish family study.
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pubmed:affiliation |
Turku Immunology Centre and Department of Virology, University of Turku, Kiinamyllynkatu 13, FIN-20520, Turku, Finland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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