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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2002-1-4
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pubmed:abstractText |
Contraction of fibroblasts and the resultant tractional force is a contributing factor to fibrotic diseases of the eye, such as proliferative vitreoretinopathy (PVR). Transforming growth factor (TGF)-beta is abundant in the eye, and is one of the growth factors thought to contribute to the development of PVR. A second is platelet-derived growth factor (PDGF). In the current study, the relationship between TGFbeta1 and PDGF was investigated at the level of cellular contraction.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0146-0404
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
43
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
41-6
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pubmed:dateRevised |
2011-6-6
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pubmed:meshHeading |
pubmed-meshheading:11773010-Animals,
pubmed-meshheading:11773010-Collagen Type I,
pubmed-meshheading:11773010-Fibroblasts,
pubmed-meshheading:11773010-Immunoblotting,
pubmed-meshheading:11773010-Mice,
pubmed-meshheading:11773010-Phosphorylation,
pubmed-meshheading:11773010-Platelet-Derived Growth Factor,
pubmed-meshheading:11773010-Precipitin Tests,
pubmed-meshheading:11773010-Rabbits,
pubmed-meshheading:11773010-Receptor, Platelet-Derived Growth Factor alpha,
pubmed-meshheading:11773010-Transforming Growth Factor beta,
pubmed-meshheading:11773010-Transforming Growth Factor beta1,
pubmed-meshheading:11773010-Tyrosine,
pubmed-meshheading:11773010-Vitreous Body
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pubmed:year |
2002
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pubmed:articleTitle |
TGFbeta1-dependent contraction of fibroblasts is mediated by the PDGFalpha receptor.
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pubmed:affiliation |
Department of Ophthalmology, The Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts 02114, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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