Source:http://linkedlifedata.com/resource/pubmed/id/11772517
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2-3
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pubmed:dateCreated |
2002-1-4
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pubmed:abstractText |
IL-6 in vitro production, as well as the serum/plasma concentration of the cytokine, increase with age. In the present investigation, a total of 62 individuals (31 males and 31 females), aged from 29 to 93 years of age (mean age of males: 60.4 years; mean age of females: 59.4 years) were assessed for IL-6 plasma concentration, and for IL-6 in vitro production, using supernatants of 4h cultured adherent peripheral blood mononuclear cells (aPBMC). The subjects were examined for a C to G transition at nucleotide -174 of the IL-6 gene promoter (-174 C/G locus), and were classified as C allele carriers (C+) or non-carriers (C-). We found that: (i) aPBMC from C+ individuals produced smaller amounts of IL-6 in vitro than C- individuals; (ii) IL-6 production by aPBMC increased with age in C+ but not in C- subjects; (iii) there was no correlation between IL-6 plasma levels and in vitro IL-6 production by aPBMC; (iv) IL-6 C+ individuals had lower plasma levels than C- individuals, and this phenomenon was significant only in men. On the whole our data indicate that the production of IL-6 is genetically controlled and age- and gender-dependent.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0531-5565
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pubmed:author |
pubmed-author:BonafèMassimilianoM,
pubmed-author:CardelliMaurizioM,
pubmed-author:CavalloneLucaL,
pubmed-author:FranceschiClaudioC,
pubmed-author:GiampieriClaudiaC,
pubmed-author:GiovagnettiSimonaS,
pubmed-author:LisaRosamariaR,
pubmed-author:MarchegianiFrancescaF,
pubmed-author:MoresiRaffaellaR,
pubmed-author:MugianesiElenaE,
pubmed-author:OlivieriFabiolaF,
pubmed-author:StecconiRosaliaR
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pubmed:issnType |
Print
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pubmed:volume |
37
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
309-14
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11772517-Adult,
pubmed-meshheading:11772517-Aged,
pubmed-meshheading:11772517-Aged, 80 and over,
pubmed-meshheading:11772517-Aging,
pubmed-meshheading:11772517-Cells, Cultured,
pubmed-meshheading:11772517-Cytidine,
pubmed-meshheading:11772517-Female,
pubmed-meshheading:11772517-Genetic Variation,
pubmed-meshheading:11772517-Guanine,
pubmed-meshheading:11772517-Humans,
pubmed-meshheading:11772517-Interleukin-6,
pubmed-meshheading:11772517-Leukocytes, Mononuclear,
pubmed-meshheading:11772517-Male,
pubmed-meshheading:11772517-Middle Aged
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pubmed:articleTitle |
The -174 C/G locus affects in vitro/in vivo IL-6 production during aging.
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pubmed:affiliation |
Direzione Scientifica Italian National Research Centers on Aging (INRCA), Via S. Margherita, n.5, 60121 Ancona, Italy.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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