Source:http://linkedlifedata.com/resource/pubmed/id/11770033
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
2001-12-24
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| pubmed:abstractText |
Coronary artery bypass grafting (CABG) using cardiopulmonary bypass (CPB) can lead to a systemic inflammatory response syndrome with organ failure and increased morbidity and mortality. The mechanisms of these findings are still under discussion. We investigated whether anti-endotoxin core antibodies, endotoxin, and proinflammatory cytokines influence the clinical course after cardiac surgery. Seventy-eight patients undergoing CABG using CPB were investigated. Anti-endotoxin core antibodies, endotoxin, interleukin (IL)-6, IL-8, IL-1beta, and TNF-alpha were measured 24 h preoperatively and up to 72 h postoperatively. Patients with a postoperative mechanical ventilation time below 24 h (n = 65; Group A) were compared to patients with prolonged respirator therapy (>24 h; n = 13; Group B). Preoperative antibody levels were significantly lower in Group B (P < 0.001). In this group, antibody levels remained decreased during the observation period (P < 0.001). Endotoxin significantly increased 30' postoperatively in both groups (P < 0.002). The increase in Group B was 3-fold higher (P< 0.001). IL-8 increased postoperatively in both groups, peaking 3 h after surgery (P < 0.001). In Group B, the IL-8 release was significantly higher than in Group A (P < 0.001). IL-6 significantly increased in both groups, reaching its maximum 24 h postoperatively (P < 0.001). No differences between groups were observed. No significant changes of IL-1beta and TNF-alpha were observed. We conclude that anti-endotoxin core antibodies may be predictive of adverse outcome after cardiac surgery. The imbalance between antibodies and endotoxin results in an exaggerated increase in endotoxin and IL-8 with an impact on clinical outcome.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Endotoxins,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-8,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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| pubmed:status |
MEDLINE
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| pubmed:issn |
1073-2322
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
16 Suppl 1
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
44-50
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| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:11770033-Aged,
pubmed-meshheading:11770033-Antibodies, Bacterial,
pubmed-meshheading:11770033-Cardiopulmonary Bypass,
pubmed-meshheading:11770033-Coronary Artery Bypass,
pubmed-meshheading:11770033-Cytokines,
pubmed-meshheading:11770033-Endotoxins,
pubmed-meshheading:11770033-Female,
pubmed-meshheading:11770033-Humans,
pubmed-meshheading:11770033-Inflammation,
pubmed-meshheading:11770033-Interleukin-1,
pubmed-meshheading:11770033-Interleukin-6,
pubmed-meshheading:11770033-Interleukin-8,
pubmed-meshheading:11770033-Male,
pubmed-meshheading:11770033-Middle Aged,
pubmed-meshheading:11770033-Postoperative Complications,
pubmed-meshheading:11770033-Prognosis,
pubmed-meshheading:11770033-Respiration, Artificial,
pubmed-meshheading:11770033-Time Factors,
pubmed-meshheading:11770033-Treatment Outcome,
pubmed-meshheading:11770033-Tumor Necrosis Factor-alpha
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| pubmed:year |
2001
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| pubmed:articleTitle |
Prediction of clinical outcome after cardiac surgery: the role of cytokines, endotoxin, and anti-endotoxin core antibodies.
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| pubmed:affiliation |
Department of Cardiothoracic Surgery, University of Muenster, Germany.
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| pubmed:publicationType |
Journal Article
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