Linked Life Data

11769456

Source:http://linkedlifedata.com/resource/pubmed/id/11769456

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2001-12-24
pubmed:abstractText
In transplantation method, efforts should be made to prevent the patient immunological reaction against the transplantation antigen. In the same time, the patient general immunological reactivity must be kept. With the increasing need for transplantation the interest for new immunosuppressive drugs has become greater. The use of immunosuppressive drugs have dated since early 1950 (azatioprin and steroids). 1960 there was the appearance of the polyclonal ALG/ATG. In 1970 the true advance has been the discovery of the first selective immunosuppressive-cyclosporin (second generation). The third generation of immunosuppressive drugs with high specific place of action, has become available now (tacrolimus, thymoglobulin, zenepax, rapamune). The purpose of this paper was to show the different groups of immunosuppressive drugs, taking into account a different place of effects and different mechanisms of their immunosuppressive action. The aim of the immunosuppressive drugs combination is to achieve the optimal immunosuppression with minimal side-effects.
pubmed:language
hrv
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0350-199X
pubmed:author
pubmed:issnType
Print
pubmed:volume
55
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
243-5
pubmed:dateRevised
2009-11-9
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
[Review of immunosuppressive drugs in organ transplantation].
pubmed:affiliation
Zavod za farmakologiju i toksikologiju, Medicinski fakultet u Tuzli.
pubmed:publicationType
Journal Article, English Abstract, Review