Linked Life Data

11769337

Source:http://linkedlifedata.com/resource/pubmed/id/11769337

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2001-12-21
pubmed:abstractText
Hemostasis after traumatic liver injury can be extremely difficult to obtain, particularly in coagulopathic patients who have suffered extensive liver damage. We determined the ability of a fibrin glue preparation (FG) to terminate ongoing bleeding using a new, clinically relevant porcine model of complex hepatic injury. Anesthetized swine (n = 6, 18 to 19 kg) received an external blast to the right upper abdomen and were immediately anticoagulated with intravenous heparin (200 u/kg). Uncontrolled hemorrhage from blast continued from time of injury (t = 0 minutes) to t = 15 minutes. Lactated Ringer's solution was infused to keep mean arterial pressure (MAP) > 80 mm Hg until the end of experiment (t = 90 minutes). Animals underwent routine surgical techniques to control bleeding, and FG was employed in the event these measures failed. Estimated blood loss and fluid resuscitation volume were measured. Serial MAP, arterial base excess, and temperature were recorded. Animals were severely injured with significant blood loss prior to laparotomy (26 +/- 6 cc/kg) and during routine surgical efforts to arrest hemorrhage (11 +/- 2 cc/kg). Bleeding could not be controlled with standard techniques in any animal. FG rapidly controlled hemorrhage and eliminated the need for packing. Re-bleeding was noted in only one animal (portal vein injury). FG can control severe hepatic hemorrhage when surgical techniques fail. Further work in the clinical arena is warranted to determine the potential benefits of FG in arresting hemorrhage in hemodynamically unstable coagulopathic patients with complex hepatic injuries.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/11769337-10452456, http://linkedlifedata.com/resource/pubmed/commentcorrection/11769337-10963535, http://linkedlifedata.com/resource/pubmed/commentcorrection/11769337-17862699, http://linkedlifedata.com/resource/pubmed/commentcorrection/11769337-2002531, http://linkedlifedata.com/resource/pubmed/commentcorrection/11769337-2072441, http://linkedlifedata.com/resource/pubmed/commentcorrection/11769337-2325186, http://linkedlifedata.com/resource/pubmed/commentcorrection/11769337-2381006, http://linkedlifedata.com/resource/pubmed/commentcorrection/11769337-2406505, http://linkedlifedata.com/resource/pubmed/commentcorrection/11769337-2457712, http://linkedlifedata.com/resource/pubmed/commentcorrection/11769337-2465752, http://linkedlifedata.com/resource/pubmed/commentcorrection/11769337-623369, http://linkedlifedata.com/resource/pubmed/commentcorrection/11769337-6374292, http://linkedlifedata.com/resource/pubmed/commentcorrection/11769337-8489321, http://linkedlifedata.com/resource/pubmed/commentcorrection/11769337-8810987, http://linkedlifedata.com/resource/pubmed/commentcorrection/11769337-9783602, http://linkedlifedata.com/resource/pubmed/commentcorrection/11769337-9932683
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0044-0086
pubmed:author
pubmed:issnType
Print
pubmed:volume
74
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
315-21
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:articleTitle
Fibrin glue eliminates the need for packing after complex liver injuries.
pubmed:affiliation
Department of Surgery, University of Miami School of Medicine, FL 33101, USA.
pubmed:publicationType
Journal Article