Source:http://linkedlifedata.com/resource/pubmed/id/11768131
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2001-12-20
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| pubmed:abstractText |
Altered platelet function has been reported in calves experimentally infected with type II bovine viral diarrhea virus (BVDV). The purpose of the present study was to further evaluate the ability of BVDV isolates to alter platelet function and to examine for the presence of a virus-platelet interaction during BVDV infection. Colostrum-deprived Holstein calves were obtained immediately after birth, housed in isolation, and assigned to 1 of 4 groups (1 control and 3 treatment groups). Control calves (n = 4) were sham inoculated, while calves in the infected groups (n = 4 for each group) were inoculated by intranasal instillation with 10(7) TCID50 of either BVDV 890 (type II), BVDV 7937 (type II), or BVDV TGAN (type I). Whole blood was collected prior to inoculation (day 0) and on days 4, 6, 8, 10, and 12 after inoculation for platelet function testing by optical aggregometry by using adenosine diphosphate and platelet activating factor. The maximum percentage aggregation and the slope of the aggregation curve decreased over time in BVDV-infected calves; however, statistically significant differences (Freidman repeated measures ANOVA on ranks, P < 0.05) were only observed in calves infected with the type II BVDV isolates. Bovine viral diarrhea virus was not isolated from control calves, but was isolated from all calves infected with both type II BVDV isolates from days 4 through 12 after inoculation. In calves infected with type I BVDV, virus was isolated from 1 of 4 calves on days 4 and 12 after inoculation and from all calves on days 6 and 8 after inoculation. Altered platelet function was observed in calves infected with both type II BVDV isolates, but was not observed in calves infected with type I BVDV. Altered platelet function may be important as a difference in virulence between type I and type II BVDV infection.
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| pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11768131-10566815,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11768131-10779200,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11768131-11042409,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11768131-12968732,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11768131-1334641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11768131-2154423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11768131-2548007,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11768131-2926719,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11768131-3010704,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11768131-7506077,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11768131-7975238,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11768131-7978652,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11768131-8053150,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11768131-8581856,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11768131-8740705,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11768131-9114964,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11768131-9249168,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11768131-9526857,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11768131-9673771,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11768131-9684044
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0830-9000
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
65
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
241-7
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| pubmed:dateRevised |
2009-11-18
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| pubmed:meshHeading |
pubmed-meshheading:11768131-Adenosine Diphosphate,
pubmed-meshheading:11768131-Animals,
pubmed-meshheading:11768131-Animals, Newborn,
pubmed-meshheading:11768131-Blood Platelets,
pubmed-meshheading:11768131-Bovine Virus Diarrhea-Mucosal Disease,
pubmed-meshheading:11768131-Cattle,
pubmed-meshheading:11768131-Diarrhea Virus 1, Bovine Viral,
pubmed-meshheading:11768131-Diarrhea Virus 2, Bovine Viral,
pubmed-meshheading:11768131-Male,
pubmed-meshheading:11768131-Platelet Aggregation,
pubmed-meshheading:11768131-Virulence
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| pubmed:year |
2001
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| pubmed:articleTitle |
Platelet aggregation responses and virus isolation from platelets in calves experimentally infected with type I or type II bovine viral diarrhea virus.
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| pubmed:affiliation |
Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing 48824-1314, USA. pwalz@vet.ksu.edu
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| pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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