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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2001-12-19
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pubmed:abstractText |
Oxygen- and nitrogen-derived free radicals and oxidants play an important role in the pathogenesis of various forms of inflammation. Recent work emphasizes the importance of oxidant-induced DNA strand breakage and activation of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) in the pathogenesis of various inflammatory diseases. We have recently demonstrated the efficacy of PJ34, a novel, potent phenanthridinone derivative PARP inhibitor, in rodent models of diabetic vascular dysfunction and stroke. Here we tested the efficacy of PARP inhibition in various models of local inflammation in rodents.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1023-3830
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pubmed:author |
pubmed-author:AbdelkarimG EGE,
pubmed-author:GettingS JSJ,
pubmed-author:HaskóGG,
pubmed-author:JagtapPP,
pubmed-author:LiaudetLL,
pubmed-author:MableyJ GJG,
pubmed-author:MartonAA,
pubmed-author:PerrettiMM,
pubmed-author:SalzmanA LAL,
pubmed-author:SorianoF GFG,
pubmed-author:SouthanG JGJ,
pubmed-author:SzabóCC,
pubmed-author:SzabóEE,
pubmed-author:VirágLL
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pubmed:issnType |
Print
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pubmed:volume |
50
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
561-9
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pubmed:dateRevised |
2008-6-5
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pubmed:meshHeading |
pubmed-meshheading:11766996-Adenosine Triphosphate,
pubmed-meshheading:11766996-Animals,
pubmed-meshheading:11766996-Anti-Inflammatory Agents,
pubmed-meshheading:11766996-Arthritis,
pubmed-meshheading:11766996-Colitis,
pubmed-meshheading:11766996-Collagen,
pubmed-meshheading:11766996-Diabetes Mellitus, Experimental,
pubmed-meshheading:11766996-Dose-Response Relationship, Drug,
pubmed-meshheading:11766996-Endotoxemia,
pubmed-meshheading:11766996-Enzyme Inhibitors,
pubmed-meshheading:11766996-Male,
pubmed-meshheading:11766996-Mice,
pubmed-meshheading:11766996-Mice, Inbred DBA,
pubmed-meshheading:11766996-NAD,
pubmed-meshheading:11766996-Peritonitis,
pubmed-meshheading:11766996-Phenanthrenes,
pubmed-meshheading:11766996-Poly(ADP-ribose) Polymerases,
pubmed-meshheading:11766996-Uveitis
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pubmed:year |
2001
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pubmed:articleTitle |
Anti-inflammatory effects of a novel, potent inhibitor of poly (ADP-ribose) polymerase.
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pubmed:affiliation |
Inotek Corporation, Beverly, MA 01915, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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