Linked Life Data

11764135

Source:http://linkedlifedata.com/resource/pubmed/id/11764135

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2001-12-14
pubmed:abstractText
The aim of this study was to establish whether a clinical trial, comparing helium-oxygen (HeO2) breathing to standard therapy, would be feasible during the out-of-hospital care of adult patients with severe asthma. Although the primary outcome in a definitive trial will be a decrease in morbidity, the present study primarily examined: (1) if the strategy could be successfully implemented in emergency ambulatory units; (2) if the research staff could enroll enough patients, given the resources. Nine patients were included in the conventional treatment group, and seven patients in the HeO2 group. Patients randomized to the HeO2 group breathed the mixture for a 12-hour period. Clinical and biological parameters improved for all patients. There was no trend towards a HeO2 benefit, whether during the initial out-of-hospital nor the ICU care. No patient was intubated within the study period. HeO2 breathing was considered to be simple to initiate, and no side effects were reported. In conclusion, while HeO2 breathing is easy to apply, even in the out-of-hospital setting, the few enrolled patients did not appear to benefit from this treatment. Regarding our low inclusion rate and the lack of positive effect trend, we believe that a large definitive trial will be difficult to initiate in such an emergency care setting.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0969-9546
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
271-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Helium-oxygen breathing in the early emergency care of acute severe asthma: a randomized pilot study.
pubmed:affiliation
Medical Emergency and Intensive Care Department, Brest University Hospital, Paris, France.
pubmed:publicationType
Journal Article, Clinical Trial, Randomized Controlled Trial, Research Support, Non-U.S. Gov't