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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2001-12-13
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pubmed:abstractText |
Osteoporosis is a major clinical problem in chronic inflammatory diseases such as rheumatoid arthritis. The mechanism of bone loss in this condition remains unclear, but previous studies have indicated that depressed bone formation plays a causal role. Since cytokine-induced nitric oxide (NO) production has been shown to inhibit osteoblast growth and differentiation in vitro, this study was undertaken to investigate the role of the inducible NO synthase (iNOS) pathway in the pathogenesis of inflammation-mediated osteoporosis (IMO) by studying mice with targeted inactivation of the iNOS gene (iNOS knockout [iNOS KO] mice).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0004-3591
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
44
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2790-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11762939-Animals,
pubmed-meshheading:11762939-Apoptosis,
pubmed-meshheading:11762939-Bone Density,
pubmed-meshheading:11762939-Female,
pubmed-meshheading:11762939-Magnesium Silicates,
pubmed-meshheading:11762939-Mice,
pubmed-meshheading:11762939-Mice, Inbred Strains,
pubmed-meshheading:11762939-Mice, Knockout,
pubmed-meshheading:11762939-Nitrates,
pubmed-meshheading:11762939-Nitric Oxide,
pubmed-meshheading:11762939-Nitric Oxide Synthase,
pubmed-meshheading:11762939-Nitric Oxide Synthase Type II,
pubmed-meshheading:11762939-Organ Size,
pubmed-meshheading:11762939-Osteoblasts,
pubmed-meshheading:11762939-Osteogenesis,
pubmed-meshheading:11762939-Osteoporosis,
pubmed-meshheading:11762939-Spleen,
pubmed-meshheading:11762939-Tibia
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pubmed:year |
2001
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pubmed:articleTitle |
Activation of the inducible nitric oxide synthase pathway contributes to inflammation-induced osteoporosis by suppressing bone formation and causing osteoblast apoptosis.
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pubmed:affiliation |
University of Aberdeen Medical School, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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