Source:http://linkedlifedata.com/resource/pubmed/id/11761481
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| pubmed:issue |
6
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| pubmed:dateCreated |
2001-12-11
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| pubmed:abstractText |
To date, high human T-cell lymphotropic virus type I proviral load in patients with human T-cell lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis has been reported and is thought to be related to the pathogenesis of human T-cell lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis. However, the proviral load in cerebrospinal fluid has not been well investigated. We measured human T-cell lymphotropic virus type I proviral load in cerebrospinal fluid cells from human T-cell lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis patients using real-time quantitative polymerase chain reaction (TaqMan). Human T-cell lymphotropic virus type I proviral load in cerebrospinal fluid cells were significantly higher than that of the matched peripheral blood mononuclear cells, and a high ratio of human T-cell lymphotropic virus type I proviral load in cerebrospinal fluid cells to peripheral blood mononuclear cells were observed in patients with short duration of illness. Human T-cell lymphotropic virus type I Tax-specific CD8+ T cells, as detected by peptide-loaded HLA tetramers, accumulated in cerebrospinal fluid compared with that in peripheral blood mononuclear cells, while the frequency of cytomegalovirus-specific CD8+ T cells in cerebrospinal fluid was reduced. These observations suggest that accumulation of both human T-cell lymphotropic virus type I-infected cells and preferential expansion of human T-cell lymphotropic virus type I-specific CD8+ cells in cerebrospinal fluid may play a role in the pathogenesis of human T-cell lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Dec
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| pubmed:issn |
0364-5134
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
50
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
807-12
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| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:11761481-Adolescent,
pubmed-meshheading:11761481-Adult,
pubmed-meshheading:11761481-Biological Markers,
pubmed-meshheading:11761481-CD8-Positive T-Lymphocytes,
pubmed-meshheading:11761481-Cerebrospinal Fluid,
pubmed-meshheading:11761481-Female,
pubmed-meshheading:11761481-Flow Cytometry,
pubmed-meshheading:11761481-Gene Products, tax,
pubmed-meshheading:11761481-Human T-lymphotropic virus 1,
pubmed-meshheading:11761481-Humans,
pubmed-meshheading:11761481-Male,
pubmed-meshheading:11761481-Middle Aged,
pubmed-meshheading:11761481-Paraparesis, Tropical Spastic,
pubmed-meshheading:11761481-Peptide Fragments,
pubmed-meshheading:11761481-Viral Load
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| pubmed:year |
2001
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| pubmed:articleTitle |
Increased HTLV-I proviral load and preferential expansion of HTLV-I Tax-specific CD8+ T cells in cerebrospinal fluid from patients with HAM/TSP.
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| pubmed:affiliation |
Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
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| pubmed:publicationType |
Journal Article
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