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rdf:type |
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lifeskim:mentions |
umls-concept:C0001272,
umls-concept:C0018787,
umls-concept:C0019409,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0080103,
umls-concept:C0205147,
umls-concept:C0205186,
umls-concept:C0205266,
umls-concept:C1519941,
umls-concept:C2003851
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pubmed:issue |
11
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pubmed:dateCreated |
2001-12-11
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pubmed:abstractText |
The monophasic action potential (MAP) technique has been validated in humans and larger animals, but, in mice, MAP recordings available to date show little resemblance to the murine ventricular transmembrane action potential (TAP) measured by conventional microelectrodes. We developed a miniaturized MAP contact electrode technique to establish in isolated mouse hearts: (1) optimal electrode size; (2) validation against TAP; (3) relationship between repolarization and refractoriness; and (4) regional repolarization differences.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1045-3873
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1286-94
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:11761418-Action Potentials,
pubmed-meshheading:11761418-Animals,
pubmed-meshheading:11761418-Electrocardiography,
pubmed-meshheading:11761418-Electrodes, Implanted,
pubmed-meshheading:11761418-Equipment Design,
pubmed-meshheading:11761418-Heart,
pubmed-meshheading:11761418-Heart Conduction System,
pubmed-meshheading:11761418-Heart Rate,
pubmed-meshheading:11761418-Male,
pubmed-meshheading:11761418-Mice,
pubmed-meshheading:11761418-Mice, Inbred ICR,
pubmed-meshheading:11761418-Models, Animal,
pubmed-meshheading:11761418-Models, Cardiovascular,
pubmed-meshheading:11761418-Myocardial Contraction,
pubmed-meshheading:11761418-Refractory Period, Electrophysiological,
pubmed-meshheading:11761418-Reproducibility of Results,
pubmed-meshheading:11761418-Statistics as Topic,
pubmed-meshheading:11761418-Time Factors
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pubmed:year |
2001
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pubmed:articleTitle |
Monophasic action potential recordings from intact mouse heart: validation, regional heterogeneity, and relation to refractoriness.
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pubmed:affiliation |
Clinical Pharmacology and Cardiology Division, Georgetown University Medical Center, Washington, DC 20422, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Validation Studies
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