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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2001-12-7
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pubmed:abstractText |
A methanolic extract of Oroxylum indicum strongly inhibited the mutagenicity of Trp-P-1 in an Ames test. The major antimutagenic constituent was identified as baicalein with an IC50 value of 2.78+/-0.15 microM. The potent antimutagenicity of the extract was correlated with the high content (3.95+/-0.43%, dry weight) of baicalein. Baicalein acted as a desmutagen since it inhibited the N-hydroxylation of Trp-P-2.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0916-8451
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
65
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2358-60
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:11758941-Antimutagenic Agents,
pubmed-meshheading:11758941-Carbolines,
pubmed-meshheading:11758941-Chromatography, High Pressure Liquid,
pubmed-meshheading:11758941-Flavanones,
pubmed-meshheading:11758941-Flavonoids,
pubmed-meshheading:11758941-Fruit,
pubmed-meshheading:11758941-Inhibitory Concentration 50,
pubmed-meshheading:11758941-Magnetic Resonance Spectroscopy,
pubmed-meshheading:11758941-Mutagenicity Tests,
pubmed-meshheading:11758941-Mutagens,
pubmed-meshheading:11758941-Plant Extracts,
pubmed-meshheading:11758941-Plants, Edible,
pubmed-meshheading:11758941-Spectrophotometry, Ultraviolet,
pubmed-meshheading:11758941-Thailand
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pubmed:year |
2001
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pubmed:articleTitle |
Antimutagenic activity against trp-P-1 of the edible Thai plant, Oroxylum indicum vent.
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pubmed:affiliation |
Japan International Research Center for Agricultural Sciences (JIRCAS), Tsukuba, Ibaraki. knakahar@affrc.go.jp
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pubmed:publicationType |
Journal Article
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