Linked Life Data

11758457

Source:http://linkedlifedata.com/resource/pubmed/id/11758457

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2001-12-7
pubmed:abstractText
MeCpGs act as ligands for nuclear factors (repressors) that are components of chromatin modification and remodelling activities. The DNA-methylation-mediated repression system (Dnmt1s, MeCPs and MBDs) is highly conserved in vertebrates. DNA methylation is essential for normal vertebrate development. It is possible (but remains unproven) that the role of DNA methylation in regulating development is highly conserved in vertebrates. In mammals, DNA methylation has an additional role in regulating the expression of imprinted genes and in controlling X-inactivation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0071-1365
pubmed:author
pubmed:issnType
Print
pubmed:volume
37
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
59-70
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
DNA methylation and control of gene expression in vertebrate development.
pubmed:affiliation
Genes and Development Group, University of Edinburgh, Department of Biomedical Sciences, Hugh Robson Building, George Square, Edinburgh EH8 9XD, Scotland, U.K. Richard.Meehan@ed.ac.uk
pubmed:publicationType
Journal Article, Review