Linked Life Data

11756976

Source:http://linkedlifedata.com/resource/pubmed/id/11756976

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2001-12-28
pubmed:abstractText
Immunosuppression during and after measles results in increased susceptibility to other infections and 1 million deaths annually. The mechanism by which measles virus (MV) induces immune suppression is incompletely understood, but a type 2 skewing of the cytokine response after infection has been documented. In vitro studies suggest that lack of interleukin (IL)-12 production by monocytes and dendritic cells plays an early role in the skewed response. In addition, immunization with an inactivated measles vaccine before measles develops appears to lead to an even stronger type 2 skewing of the cytokine response and atypical measles. In this study, the cytokine responses in rhesus macaques were compared after vaccination with live and formalin-inactivated vaccines and after challenge with MV. In vivo production of IL-12 was decreased during the viremic phase of the illness, and production of IL-4 was increased during and after atypical measles, compared with measles.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0022-1899
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
185
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
13-9
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Altered synthesis of interleukin-12 and type 1 and type 2 cytokinesin rhesus macaques during measles and atypical measles.
pubmed:affiliation
W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Hygiene and Public Health, Baltimore, Maryland 21205, USA. fpolack@jhsph.edu
pubmed:publicationType
Journal Article