Linked Life Data

11756743

Source:http://linkedlifedata.com/resource/pubmed/id/11756743

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4-5
pubmed:dateCreated
2001-12-28
pubmed:abstractText
It is neither known why hormonal and nutritional deficiencies only cause neurological abnormalities at particular periods of development, nor is it known why repair only occurs if normal metabolic status is restored within a particular temporal window. We propose that these maladies are precursor cell diseases, in which the normal balance between self-renewal and differentiation is compromised in dividing precursor cells. According to this hypothesis, the windows of vulnerability in these disorders correspond to the timing of particular transitions in CNS precursor cells, as seen in our studies on the effects of thyroid hormone and iron on the generation of oligodendrocytes and their immediate ancestor, the O-2A progenitor cell.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0378-5866
pubmed:author
pubmed:copyrightInfo
Copyright 2001 S. Karger AG, Basel
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
277-86
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Are hypothyroidism and iron deficiency precursor cell diseases?
pubmed:affiliation
Center for Cancer Biology, University of Rochester Medical Center, Rochester, NY 14642, USA. margot_mayer-proschel@urmc.rochester.edu
pubmed:publicationType
Journal Article, Review