Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2001-12-28
pubmed:abstractText
The role of vesicles in cargo transport through the Golgi apparatus has been controversial. Large forms of cargo such as protein aggregates are thought to progress through the Golgi stack by a process of cisternal maturation, balanced by a return flow of Golgi resident proteins in COPI-coated vesicles. However, whether this is the primary role of vesicles, or whether they also serve to transport small cargo molecules in a forward direction has been debated. Two papers (Martínez-Menárguez et al., 2001; Mironov et al., 2001, this issue) use sophisticated light and electron microscopy to provide evidence that the vesicular stomatitis virus membrane glycoprotein (VSV G)* is largely excluded from vesicles in vivo, and does not move between cisternae, whereas resident Golgi enzymes freely enter vesicles as predicted by the cisternal maturation model. Both papers conclude that vesicles are likely to play only a minor role in the anterograde transport of cargo through the Golgi apparatus in mammalian tissue culture cells.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/11756463-10087259, http://linkedlifedata.com/resource/pubmed/commentcorrection/11756463-10975524, http://linkedlifedata.com/resource/pubmed/commentcorrection/11756463-10995433, http://linkedlifedata.com/resource/pubmed/commentcorrection/11756463-11030615, http://linkedlifedata.com/resource/pubmed/commentcorrection/11756463-11208060, http://linkedlifedata.com/resource/pubmed/commentcorrection/11756463-11748249, http://linkedlifedata.com/resource/pubmed/commentcorrection/11756463-11748250, http://linkedlifedata.com/resource/pubmed/commentcorrection/11756463-11756473, http://linkedlifedata.com/resource/pubmed/commentcorrection/11756463-7588599, http://linkedlifedata.com/resource/pubmed/commentcorrection/11756463-7806565, http://linkedlifedata.com/resource/pubmed/commentcorrection/11756463-8252615, http://linkedlifedata.com/resource/pubmed/commentcorrection/11756463-8670420, http://linkedlifedata.com/resource/pubmed/commentcorrection/11756463-9244307, http://linkedlifedata.com/resource/pubmed/commentcorrection/11756463-9875853
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0021-9525
pubmed:author
pubmed:issnType
Print
pubmed:day
24
pubmed:volume
155
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1099-101
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Traffic through the Golgi apparatus.
pubmed:affiliation
Laboratory of Molecular Biology, Medical Research Council, Hills Road, Cambridge CB2 2QH, UK. hp@mrc-lmb.cam.ac.uk
pubmed:publicationType
Journal Article, Review