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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2001-12-28
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pubmed:abstractText |
Glomerular infiltration of monocytes/macrophages occurs in diabetic patients with nephropathy, and chemokine receptor signals are thought to play a key role in the development of nephropathy. Recently, polymorphism of the chemokine receptor (CCR)2 coding region V64I and the CCR5 promoter region 59029 (G/A) have been identified. Accordingly, we evaluated the effects of these genotypes on diabetic nephropathy. CCR2 V64I and CCR5 59029 (G/A) were detected by polymerase chain reaction-restriction fragment-length polymorphism in 401 patients with type 2 diabetes who had a serum creatinine <2.0 mg/dl. Although the CCR2 V64I genotype showed no association with nephropathy, the frequency of the CCR5 59029 A-positive genotype (G/A or A/A) was significantly higher in patients with microalbuminuria (urinary albumin-to-creatinine ratio [ACR] > or = 30 and <300 mg/gCre, 86%) and patients with macroalbuminuria (ACR > or = 300 mg/gCre, 87%) than in patients with normoalbuminuria (ACR <30 mg/gCre, 75%; P = 0.0095). Polytomic logistic regression analysis showed that the CCR5 59029 A-positive genotype was associated with nephropathy (odds ratio 2.243, P = 0.0074). These results suggest that the CCR5 promoter 59029 A genotype may be an independent risk factor for diabetic nephropathy in patients with type 2 diabetes.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CCR2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, HDL,
http://linkedlifedata.com/resource/pubmed/chemical/Creatinine,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Transposable Elements,
http://linkedlifedata.com/resource/pubmed/chemical/Hemoglobin A, Glycosylated,
http://linkedlifedata.com/resource/pubmed/chemical/Peptidyl-Dipeptidase A,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CCR2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CCR5,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Chemokine
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0012-1797
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
51
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
238-42
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:11756347-Albuminuria,
pubmed-meshheading:11756347-Asian Continental Ancestry Group,
pubmed-meshheading:11756347-Cholesterol,
pubmed-meshheading:11756347-Cholesterol, HDL,
pubmed-meshheading:11756347-Creatinine,
pubmed-meshheading:11756347-DNA Transposable Elements,
pubmed-meshheading:11756347-Diabetes Mellitus, Type 2,
pubmed-meshheading:11756347-Diabetic Nephropathies,
pubmed-meshheading:11756347-Female,
pubmed-meshheading:11756347-Genotype,
pubmed-meshheading:11756347-Hemoglobin A, Glycosylated,
pubmed-meshheading:11756347-Humans,
pubmed-meshheading:11756347-Japan,
pubmed-meshheading:11756347-Male,
pubmed-meshheading:11756347-Middle Aged,
pubmed-meshheading:11756347-Peptidyl-Dipeptidase A,
pubmed-meshheading:11756347-Receptors, CCR2,
pubmed-meshheading:11756347-Receptors, CCR5,
pubmed-meshheading:11756347-Receptors, Chemokine,
pubmed-meshheading:11756347-Sequence Deletion,
pubmed-meshheading:11756347-Smoking
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pubmed:year |
2002
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pubmed:articleTitle |
Chemokine receptor genotype is associated with diabetic nephropathy in Japanese with type 2 diabetes.
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pubmed:affiliation |
Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine, Tokyo, Japan.
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pubmed:publicationType |
Journal Article
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