Linked Life Data

11755336

Source:http://linkedlifedata.com/resource/pubmed/id/11755336

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2001-12-28
pubmed:abstractText
Conformational constraint has been used as the key design element in the identification of a series of potent and selective ET(A) antagonists. The most potent antagonist, 32, (ET(A) IC(50)=0.55nM) is 722-fold selective over the ET(B) receptor, as measured by binding experiments.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0960-894X
pubmed:author
pubmed:issnType
Print
pubmed:day
21
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
125-8
pubmed:dateRevised
2004-1-20
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
The design and synthesis of a novel series of indole derived selective ET(A) antagonists.
pubmed:affiliation
Department of Discovery Chemistry, Pfizer Central Research, Sandwich, Kent CT13 9NJ, UK. david_rawson@sandwich.pfizer.com
pubmed:publicationType
Journal Article