Linked Life Data

11755022

Source:http://linkedlifedata.com/resource/pubmed/id/11755022

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2001-12-28
pubmed:abstractText
Long-term moderate dietary restriction (DR) has been reported to extend life spans, delay the onset and decrease the incidence of a broad spectrum of age-associated diseases; however, its effect on cognition is still unclear. Our previous results indicated that long-term DR failed to retard cognitive and psychomotor aging in the inbred strain, Fischer-344 rats. In the present experiment, an anti-aging effect of DR on various types of cognitive and sensorimotor behaviors was found in F1 hybrid Fischer-344 x Brown Norway (F-344xBN) rats, while no effect of DR was detected in the second parental inbred strain, Brown-Norway (BN) rats. These findings show that the lack of an effect of DR on cognitive aging, which was previously found in Fischer-344 rats, is not a universal phenomenon. Instead, the effect of DR may depend upon the genetic makeup of the animals. Thus, a more diverse genetic milieu, such as in hybrid rats, relative to inbred rats, may increase the susceptibility to an effect of DR on age-related cognitive decline.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0197-4580
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
75-86
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:articleTitle
Retardation of cognitive aging by life-long diet restriction: implications for genetic variance.
pubmed:affiliation
Neuromnemonics Laboratory, Department of Psychology, The Johns Hopkins University, Baltimore, MD 21218, USA. Alicja@jhu.edu
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.