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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2001-12-25
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pubmed:abstractText |
Defective DNA mismatch repair (MMR) appears to be rare in nonsmall cell carcinomas of the lung. Defective DNA MMR results from genetic or epigenetic alterations that inactivate the DNA MMR genes hMLH1 or hMSH2, and rarely hMSH6. The loss of normal DNA MMR is thought to promote tumorigenesis by accelerating the accumulation of mutations in oncogenes and tumor suppressor genes. Inactivation of hMLH1, hMSH2, and hMSH6 is observed as a loss of expression of these proteins by immunohistochemistry. Bronchioloalveolar carcinoma is a subtype of adenocarcinoma with distinctive clinical and pathologic features.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/G-T mismatch-binding protein,
http://linkedlifedata.com/resource/pubmed/chemical/MLH1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/MSH2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/MutS Homolog 2 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0008-543X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2001 American Cancer Society.
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
92
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2898-901
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pubmed:dateRevised |
2010-3-24
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pubmed:meshHeading |
pubmed-meshheading:11753964-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:11753964-Adenocarcinoma, Bronchiolo-Alveolar,
pubmed-meshheading:11753964-Aged,
pubmed-meshheading:11753964-Aged, 80 and over,
pubmed-meshheading:11753964-Base Pair Mismatch,
pubmed-meshheading:11753964-Carrier Proteins,
pubmed-meshheading:11753964-DNA Repair,
pubmed-meshheading:11753964-DNA-Binding Proteins,
pubmed-meshheading:11753964-Female,
pubmed-meshheading:11753964-Humans,
pubmed-meshheading:11753964-Immunohistochemistry,
pubmed-meshheading:11753964-Lung Neoplasms,
pubmed-meshheading:11753964-Male,
pubmed-meshheading:11753964-Middle Aged,
pubmed-meshheading:11753964-MutS Homolog 2 Protein,
pubmed-meshheading:11753964-Neoplasm Proteins,
pubmed-meshheading:11753964-Nuclear Proteins,
pubmed-meshheading:11753964-Proto-Oncogene Proteins
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pubmed:year |
2001
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pubmed:articleTitle |
DNA mismatch repair genes hMLH1, hMSH2, and hMSH6 are not inactivated in bronchioloalveolar carcinomas of the lung.
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pubmed:affiliation |
Department of Laboratory Medicine and Pathology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA. aubry.mariechristine@mayo.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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