Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2001-12-25
pubmed:abstractText
The aim of this study was to investigate feasibility, tolerability and efficacy of rituximab-supplemented high-dose sequential chemotherapy (R-HDS) with peripheral blood progenitor cell autografting as frontline or salvage treatment in patients with advanced non-Hodgkin's lymphoma (NHL). Thirty-two patients have been treated: 14 at disease onset and 18 with relapsed or progressive disease. R-HDS regimens included six courses of rituximab. Rituximab was delivered either concurrently with high-dose chemotherapy to exploit the in vivo purging properties of the drug as well as at the end of the treatment plan to target minimal residual disease. All patients treated at disease onset completed their treatment with no life-threatening toxicity, while two toxic deaths due to severe bilateral pneumonia were observed among patients treated due to relapsed or refractory disease. Thirteen of 14 patients treated up-front achieved CR. Among pre-treated patients 10 of 18 achieved CR with better results in patients with relapsed (seven of eight) compared to progressive disease (three of 10). PCR analysis was carried out in indolent lymphoma patients: nine of nine follicular lymphomas and three of six CD5-positive NHL collected PCR-negative peripheral blood progenitor cell harvests. The results of this pilot study show that R-HDS is feasible and effective with acceptable toxicity when used at disease onset. In pre-treated patients this treatment also showed promising results, although the risk of severe infections needs to be considered.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0887-6924
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1941-9
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:11753616-Adult, pubmed-meshheading:11753616-Antibodies, Monoclonal, pubmed-meshheading:11753616-Antibodies, Monoclonal, Murine-Derived, pubmed-meshheading:11753616-Antineoplastic Combined Chemotherapy Protocols, pubmed-meshheading:11753616-Drug Administration Schedule, pubmed-meshheading:11753616-Feasibility Studies, pubmed-meshheading:11753616-Female, pubmed-meshheading:11753616-Hematopoietic Stem Cell Transplantation, pubmed-meshheading:11753616-Humans, pubmed-meshheading:11753616-Immunotherapy, pubmed-meshheading:11753616-Lymphoma, Non-Hodgkin, pubmed-meshheading:11753616-Male, pubmed-meshheading:11753616-Middle Aged, pubmed-meshheading:11753616-Neoplasm, Residual, pubmed-meshheading:11753616-Polymerase Chain Reaction, pubmed-meshheading:11753616-Salvage Therapy, pubmed-meshheading:11753616-Transplantation, Autologous, pubmed-meshheading:11753616-Treatment Outcome
pubmed:year
2001
pubmed:articleTitle
Concurrent administration of high-dose chemotherapy and rituximab is a feasible and effective chemo/immunotherapy for patients with high-risk non-Hodgkin's lymphoma.
pubmed:affiliation
Divisione Universitaria di Ematologia-Dipartimento di Medicina ed Oncologia Sperimentale, Università di Torino, Torino, Italy.
pubmed:publicationType
Journal Article, Clinical Trial, Research Support, Non-U.S. Gov't