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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2001-12-25
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pubmed:abstractText |
The clearance and activity of different types of lipopolysaccharide (LPS) released during infection with Gram-negative bacteria were investigated. When highly purified preparations differing in their specific endotoxin activity were administered intravenously to mice, the clearance of rough (R)-form LPS preparations from Salmonella minnesota and Escherichia coli was much faster than that of a smooth (S)-form LPS preparation from Salmonella abortus equi, but slower than that of lipo-oligosaccharides (LOS) preparations from Bordetella pertussis and Helicobacter pylori. After intraperitoneal infection with 10(7) and 10(8) CFU E. coli O111:B4, relatively high levels of LPS were detected dose-dependently in the plasma of infected mice and persisted for a long time. In addition, plasma sCD14 levels in infected mice were higher than in LPS-administered mice. These results indicate that continuously higher levels of plasma LPS followed by stronger host responses occur during infection and suggest that these differences between LPS-administered and infected mice should be taken into consideration when analyzing host responses induced by LPS.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0968-0519
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
421-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11753211-Animals,
pubmed-meshheading:11753211-Antigens, Bacterial,
pubmed-meshheading:11753211-Antigens, CD14,
pubmed-meshheading:11753211-Autoantigens,
pubmed-meshheading:11753211-Blotting, Western,
pubmed-meshheading:11753211-Colony Count, Microbial,
pubmed-meshheading:11753211-Cytokines,
pubmed-meshheading:11753211-Cytotoxicity Tests, Immunologic,
pubmed-meshheading:11753211-Dose-Response Relationship, Immunologic,
pubmed-meshheading:11753211-Escherichia coli,
pubmed-meshheading:11753211-Escherichia coli Infections,
pubmed-meshheading:11753211-Female,
pubmed-meshheading:11753211-Gram-Negative Bacterial Infections,
pubmed-meshheading:11753211-Injections, Intravenous,
pubmed-meshheading:11753211-Limulus Test,
pubmed-meshheading:11753211-Lipopolysaccharides,
pubmed-meshheading:11753211-Metabolic Clearance Rate,
pubmed-meshheading:11753211-Mice,
pubmed-meshheading:11753211-Mice, Inbred ICR,
pubmed-meshheading:11753211-Mice, Inbred Strains
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pubmed:year |
2001
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pubmed:articleTitle |
Differential clearance and induction of host responses by various administered or released lipopolysaccharides.
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pubmed:affiliation |
Department of Biosciences, School of Science, Kitasato University, Sagamihara, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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