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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2001-12-25
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pubmed:abstractText |
CD8(+) T cells are a major component of the adaptive response of a host to infections by viruses and other intracellular pathogenic agents. However, because of the intrinsic immaturity of the immune system of neonatal animals, neonates are highly sensitive to a variety of pathogens and may be unable to respond in a protective manner. Here we explore whether a hyperattenuated strain of Listeria monocytogenes that can be used as a live vaccine vector in adults is safe and able to induce an effective response in neonates. We answer both questions affirmatively.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11752181-10228039,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11752181-10438968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11752181-10679069,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11752181-10684276,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11752181-10763708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11752181-10763709,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11752181-10861027,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11752181-11024127,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11752181-11046003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11752181-11119576,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11752181-11145668,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11752181-11207297,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11752181-11222702,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11752181-11242050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11752181-11264538,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11752181-13099277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11752181-1470917,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11752181-7594479,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11752181-7892606,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11752181-8476559,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11752181-8596932,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11752181-8596933,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11752181-8596934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11752181-9190958,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11752181-9551927,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11752181-9673233,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11752181-9743362
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
76
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
918-22
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:11752181-AIDS Vaccines,
pubmed-meshheading:11752181-Animals,
pubmed-meshheading:11752181-Animals, Newborn,
pubmed-meshheading:11752181-Female,
pubmed-meshheading:11752181-Gene Products, gag,
pubmed-meshheading:11752181-Genetic Engineering,
pubmed-meshheading:11752181-HIV Antigens,
pubmed-meshheading:11752181-HIV Infections,
pubmed-meshheading:11752181-HIV-1,
pubmed-meshheading:11752181-Listeria monocytogenes,
pubmed-meshheading:11752181-Male,
pubmed-meshheading:11752181-Mice,
pubmed-meshheading:11752181-Survival Rate,
pubmed-meshheading:11752181-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:11752181-Vaccines, Attenuated,
pubmed-meshheading:11752181-Vaccines, Synthetic
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pubmed:year |
2002
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pubmed:articleTitle |
Safety and immunogenicity in neonatal mice of a hyperattenuated Listeria vaccine directed against human immunodeficiency virus.
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pubmed:affiliation |
Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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