Source:http://linkedlifedata.com/resource/pubmed/id/11751997
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2001-12-25
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| pubmed:abstractText |
To study the phenotypic and functional changes in naive type II collagen (CII)-specific autoimmune T cells following a tolerogenic signal, a TCR-transgenic (Tg) mouse model of collagen-induced arthritis was developed. These Tg mice express an I-A(q)-restricted CII (260-267)-specific TCR that confers severe accelerated autoimmune arthritis following immunization with CII. Despite the fact that >90% of the alphabeta T cells express the Tg, these mice can be rendered completely tolerant to the induction of arthritis by i.v. administration of 200 microg of CII. As early as 24 h after CII administration, CII-specific T cells demonstrated a decreased ability to proliferate in response to the CII immunodominant peptide and phenotypically altered the expression of L-selectin to CD62L(low) and of phagocytic glycoprotein-1 to CD44(high), expression levels consistent with the phenotype of memory T cells. In addition, they up-regulated the expression of the activation markers CD71 and CD69. Functionally, following tolerogenic stimulation, the CII-specific T cells produced similar levels of IL-2 in comparison to controls when challenged with CII peptide, however, by 48 h after exposure to tolerogen, IL-2 production dropped and was replaced by high levels of IL-10 and IL-4. Based on their production of Th2 cytokines, these data suggest that T regulatory cells expressing activation and memory markers are induced by the tolerogen and may exert their influence via cytokines to protect the animals from the induction of arthritis.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
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| pubmed:issn |
0022-1767
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:day |
1
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| pubmed:volume |
168
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
490-8
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:11751997-Animals,
pubmed-meshheading:11751997-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:11751997-Arthritis, Experimental,
pubmed-meshheading:11751997-Autoimmune Diseases,
pubmed-meshheading:11751997-Autoimmunity,
pubmed-meshheading:11751997-Cells, Cultured,
pubmed-meshheading:11751997-Collagen Type II,
pubmed-meshheading:11751997-Cytokines,
pubmed-meshheading:11751997-Genes, T-Cell Receptor,
pubmed-meshheading:11751997-Immunophenotyping,
pubmed-meshheading:11751997-Injections, Intravenous,
pubmed-meshheading:11751997-Kinetics,
pubmed-meshheading:11751997-Lymphocyte Activation,
pubmed-meshheading:11751997-Mice,
pubmed-meshheading:11751997-Mice, Inbred C3H,
pubmed-meshheading:11751997-Mice, Inbred C57BL,
pubmed-meshheading:11751997-Mice, Transgenic,
pubmed-meshheading:11751997-Self Tolerance,
pubmed-meshheading:11751997-T-Lymphocyte Subsets,
pubmed-meshheading:11751997-T-Lymphocytes
|
| pubmed:year |
2002
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| pubmed:articleTitle |
Detection of early changes in autoimmune T cell phenotype and function following intravenous administration of type II collagen in a TCR-transgenic model.
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| pubmed:affiliation |
Veterans Affairs Medical Center, 1030 Jefferson Avenue, Memphis, TN 38104, USA. dbrand@utmem.edu
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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