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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2001-12-25
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pubmed:databankReference |
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pubmed:abstractText |
We report on a case of a postneurosurgical meningitis due to ceftriaxone-susceptible Proteus penneri, with selection of a ceftriaxone-resistant isolate following treatment with ceftriaxone. The isolates presented identical patterns by pulsed-field gel electrophoresis and produced a single beta-lactamase named HugA with an isoelectric point of 6.7. The ceftriaxone-resistant isolate hyperproduced the beta-lactamase (increase in the level of production, about 90-fold). The sequences of the hugA beta-lactamase gene and its regulator, hugR, were identical in both P. penneri strains and had 85.96% homology with those of Proteus vulgaris. The HugA beta-lactamase belongs to molecular class A, and the transcriptional regulator HugR belongs to the LysR family.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11751137-11023955,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11751137-1804001,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11751137-1892329,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11751137-2607970,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11751137-3489701,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11751137-3571463,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11751137-4198636,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11751137-7050147,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11751137-7574506,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11751137-7824319,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11751137-7957242,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11751137-8043607,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11751137-8452343,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11751137-8593009,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11751137-8665470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11751137-8864850,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11751137-9106365,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11751137-96731
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0066-4804
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
46
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
216-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:11751137-Adult,
pubmed-meshheading:11751137-Amino Acid Sequence,
pubmed-meshheading:11751137-Base Sequence,
pubmed-meshheading:11751137-Ceftriaxone,
pubmed-meshheading:11751137-Chromosomes, Bacterial,
pubmed-meshheading:11751137-DNA, Bacterial,
pubmed-meshheading:11751137-Drug Resistance,
pubmed-meshheading:11751137-Humans,
pubmed-meshheading:11751137-Meningitis, Bacterial,
pubmed-meshheading:11751137-Molecular Sequence Data,
pubmed-meshheading:11751137-Postoperative Complications,
pubmed-meshheading:11751137-Proteus,
pubmed-meshheading:11751137-beta-Lactamases
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pubmed:year |
2002
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pubmed:articleTitle |
Postneurosurgical meningitis due to Proteus penneri with selection of a ceftriaxone-resistant isolate: analysis of chromosomal class A beta-lactamase HugA and its LysR-type regulatory protein HugR.
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pubmed:affiliation |
Central Laboratory of Bacteriology, University Hospital, Geneva, Switzerland. nliassine@unilabs.ch
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pubmed:publicationType |
Journal Article,
Case Reports
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