Linked Life Data

1174979

Source:http://linkedlifedata.com/resource/pubmed/id/1174979

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1975-12-23
pubmed:abstractText
Cerebellar inhibition of spontaneous or homocysteic acid-induced activity of dorsal Deiters' neurons was studied in cats anesthetized with chloralose-urethane. Following intravenous lidocaine (5-10 mg/kg), cerebellar inhibition was not reduced but postinhibitory peaks (PIPs) appeared in the poststimulus histograms. The number of PIPs increased as variability in firing rate decreased after lidocaine. The frequency of PIPs observed in the histograms approximated the monitored firing rates of the cells. The peaks observed in autocorrelograms constructed after lidocaine had the same frequency, structure and variability as the PIPs. In 'dot diagrams', only one spike per corresponding PIP was observed. Similar PIPs were observed in poststimulus histograms constructed during inhibition of crayfish stretch receptor neurons which fired regularly in the absence of lidocaine. These studies indicate that the postinhibitory peaks and silent periods were due to synchronized firing of Deiters' neurons induced by cerebellar inhibition, which was detectable only after lidocaine regularized the firing of Deiters' neurons.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
93
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
409-18
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
Rhythmic firing of Deiters' neurons and synchronization by cerebellar inhibition in lidocaine-treated cats.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.