Linked Life Data

11748837

Source:http://linkedlifedata.com/resource/pubmed/id/11748837

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2001-12-18
pubmed:abstractText
Anteroposterior (A/P) patterning of the vertebrate neurectoderm begins early during development. In vitro explant assays have been used to show that an A/P subdivision of the zebrafish neurectoderm is in place by early gastrulation. However, no direct markers of this subdivision had been described. We report isolation of two members of the zic gene family, zic2 and zic3, which mark distinct regions in the developing nervous system. zic3 is expressed in early gastrula embryos in a posterior domain, directly demonstrating that A/P pattern is present in the future neurectoderm by this stage. Analysis of mutants in genes encoding bone morphogenetic proteins (BMPs) shows that dorsal restriction of zic3 expression requires intact BMP function, and that posterior restriction of zic3 expression is regulated independently of BMP signaling. These data show an early subdivision of the A/P axis in the presumptive neurectoderm.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1058-8388
pubmed:author
pubmed:copyrightInfo
Copyright 2001 Wiley-Liss, Inc.
pubmed:issnType
Print
pubmed:volume
222
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
688-93
pubmed:dateRevised
2004-12-3
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
zic Gene expression marks anteroposterior pattern in the presumptive neurectoderm of the zebrafish gastrula.
pubmed:affiliation
Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA.
pubmed:publicationType
Journal Article