| pubmed-article:11747025 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11747025 | lifeskim:mentions | umls-concept:C0003504 | lld:lifeskim |
| pubmed-article:11747025 | lifeskim:mentions | umls-concept:C0205082 | lld:lifeskim |
| pubmed-article:11747025 | lifeskim:mentions | umls-concept:C0301630 | lld:lifeskim |
| pubmed-article:11747025 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:11747025 | pubmed:dateCreated | 2001-12-17 | lld:pubmed |
| pubmed-article:11747025 | pubmed:abstractText | This study was designed to assess the effects of afterload reduction in asymptomatic patients with severe aortic regurgitation (AR) and maintained LV function by cine-MRI. We studied 13 patients at baseline and after 0.2 mg/kg Hydralazine (I.V.). Patients were stratified according to the volumetric LV response to acute afterload reduction: Group I comprised patients with improved LV response; Group II comprised patients with unchanged or deteriorated LV response. Baseline LV function and severity of AR were not significantly different between groups. However, regurgitant fraction decreased (50 +/- 12 vs. 36 +/- 9%; P < 0.03) and cardiac output increased (4.9 +/- 1.4 vs. 7.1 +/- 1.6l/minute; P < 0,001) in Group I and remained unchanged in Group II (54 +/- 10 vs. 55 +/- 10%, P = n.s. and 5.5 +/- 1.4 vs. 6.6 +/- 0.9l/minute; P = n.s.) during maximal vasodilation. Beat-to-beat analysis revealed a decrease of left ventricular endsystolic volume index in group I (48 +/- 13 vs. 37 +/- 9 ml/beat; P < 0.05) and no change in group II (61 +/- 20 vs. 62 +/- 20 ml/beat; P = n.s.). In the natural history of chronic AR, the absence of improved LV performance during acute vasodilation using beat-to-beat analysis by MRI may identify patients with more advanced cardiac adaptation to chronic volume overload. | lld:pubmed |
| pubmed-article:11747025 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11747025 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11747025 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11747025 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11747025 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11747025 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11747025 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:11747025 | pubmed:issn | 1053-1807 | lld:pubmed |
| pubmed-article:11747025 | pubmed:author | pubmed-author:FrankHH | lld:pubmed |
| pubmed-article:11747025 | pubmed:author | pubmed-author:HoffmannUU | lld:pubmed |
| pubmed-article:11747025 | pubmed:author | pubmed-author:KaiserBB | lld:pubmed |
| pubmed-article:11747025 | pubmed:author | pubmed-author:StefenelliTT | lld:pubmed |
| pubmed-article:11747025 | pubmed:author | pubmed-author:GlobitsSS | lld:pubmed |
| pubmed-article:11747025 | pubmed:author | pubmed-author:KlaarUU | lld:pubmed |
| pubmed-article:11747025 | pubmed:copyrightInfo | Copyright 2001 Wiley-Liss, Inc. | lld:pubmed |
| pubmed-article:11747025 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11747025 | pubmed:volume | 14 | lld:pubmed |
| pubmed-article:11747025 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11747025 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11747025 | pubmed:pagination | 693-7 | lld:pubmed |
| pubmed-article:11747025 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:11747025 | pubmed:meshHeading | pubmed-meshheading:11747025... | lld:pubmed |
| pubmed-article:11747025 | pubmed:meshHeading | pubmed-meshheading:11747025... | lld:pubmed |
| pubmed-article:11747025 | pubmed:meshHeading | pubmed-meshheading:11747025... | lld:pubmed |
| pubmed-article:11747025 | pubmed:meshHeading | pubmed-meshheading:11747025... | lld:pubmed |
| pubmed-article:11747025 | pubmed:meshHeading | pubmed-meshheading:11747025... | lld:pubmed |
| pubmed-article:11747025 | pubmed:meshHeading | pubmed-meshheading:11747025... | lld:pubmed |
| pubmed-article:11747025 | pubmed:meshHeading | pubmed-meshheading:11747025... | lld:pubmed |
| pubmed-article:11747025 | pubmed:meshHeading | pubmed-meshheading:11747025... | lld:pubmed |
| pubmed-article:11747025 | pubmed:meshHeading | pubmed-meshheading:11747025... | lld:pubmed |
| pubmed-article:11747025 | pubmed:meshHeading | pubmed-meshheading:11747025... | lld:pubmed |
| pubmed-article:11747025 | pubmed:meshHeading | pubmed-meshheading:11747025... | lld:pubmed |
| pubmed-article:11747025 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11747025 | pubmed:articleTitle | Afterload reduction in severe aortic regurgitation. | lld:pubmed |
| pubmed-article:11747025 | pubmed:affiliation | Department of Radiology, University Hospital Vienna, Vienna, Austria. Hoffmann@helix.mgh.harvard.edu | lld:pubmed |
| pubmed-article:11747025 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11747025 | pubmed:publicationType | Comparative Study | lld:pubmed |
