Source:http://linkedlifedata.com/resource/pubmed/id/11747025
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
2001-12-17
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pubmed:abstractText |
This study was designed to assess the effects of afterload reduction in asymptomatic patients with severe aortic regurgitation (AR) and maintained LV function by cine-MRI. We studied 13 patients at baseline and after 0.2 mg/kg Hydralazine (I.V.). Patients were stratified according to the volumetric LV response to acute afterload reduction: Group I comprised patients with improved LV response; Group II comprised patients with unchanged or deteriorated LV response. Baseline LV function and severity of AR were not significantly different between groups. However, regurgitant fraction decreased (50 +/- 12 vs. 36 +/- 9%; P < 0.03) and cardiac output increased (4.9 +/- 1.4 vs. 7.1 +/- 1.6l/minute; P < 0,001) in Group I and remained unchanged in Group II (54 +/- 10 vs. 55 +/- 10%, P = n.s. and 5.5 +/- 1.4 vs. 6.6 +/- 0.9l/minute; P = n.s.) during maximal vasodilation. Beat-to-beat analysis revealed a decrease of left ventricular endsystolic volume index in group I (48 +/- 13 vs. 37 +/- 9 ml/beat; P < 0.05) and no change in group II (61 +/- 20 vs. 62 +/- 20 ml/beat; P = n.s.). In the natural history of chronic AR, the absence of improved LV performance during acute vasodilation using beat-to-beat analysis by MRI may identify patients with more advanced cardiac adaptation to chronic volume overload.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1053-1807
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pubmed:author | |
pubmed:copyrightInfo |
Copyright 2001 Wiley-Liss, Inc.
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pubmed:issnType |
Print
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
693-7
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:11747025-Adult,
pubmed-meshheading:11747025-Aortic Valve Insufficiency,
pubmed-meshheading:11747025-Feasibility Studies,
pubmed-meshheading:11747025-Female,
pubmed-meshheading:11747025-Hemodynamics,
pubmed-meshheading:11747025-Humans,
pubmed-meshheading:11747025-Hydralazine,
pubmed-meshheading:11747025-Magnetic Resonance Imaging, Cine,
pubmed-meshheading:11747025-Male,
pubmed-meshheading:11747025-Vasodilator Agents,
pubmed-meshheading:11747025-Ventricular Function, Left
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pubmed:year |
2001
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pubmed:articleTitle |
Afterload reduction in severe aortic regurgitation.
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pubmed:affiliation |
Department of Radiology, University Hospital Vienna, Vienna, Austria. Hoffmann@helix.mgh.harvard.edu
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pubmed:publicationType |
Journal Article,
Comparative Study
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