Linked Life Data

11746532

Source:http://linkedlifedata.com/resource/pubmed/id/11746532

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2001-12-17
pubmed:abstractText
We attempted to determine whether various cytokine levels in the serum and synovial fluid (SF) of rheumatoid arthritis (RA) patients are influenced by the performance of filtration leukocytapheresis (LCP). The filtration LCP procedure that used a Cellsorba column (LCP group: n=22; responder subgroup: n=17, non-responder subgroup: n=5) or sham apheresis (control group; n=7) was repeated three times at 1-week intervals. Serum (LCP group, n=22; control group, n=7) and SF (LCP group, n=6; control group, n=3) samples were collected before and after LCP. Levels of tumor necrosis factor alpha (TNFalpha), interleukins (IL-1 beta, IL-2, IL-6, IL-8, IL-10, and IL-15), granulocyte-macrophage colony-stimulating factor (GM-CSF), monocyte chemoattractant protein-1 (MCP-1), RANTES were measured by an enzyme-linked immunosorbent assay. Serum TNF alpha, IL-15, and RANTES were significantly reduced only in the LCP group. Serum IL-10 significantly increased only in the LCP group. In the LCP subgroup, serum IL-15, GM-CSF, and RANTES levels were reduced significantly, while serum IL-10 levels increased significantly only in the responder group after treatment. Serum TNF alpha levels were reduced significantly in both subgroups. Changes in serum IL-10 correlated positively with the improvement of patient's assessment of pain and global severity, and physician's assessment of global severity. These results indicate that the removal of leukocytes from the peripheral blood of RA patients provokes dynamic changes in some cytokine levels in the serum and/or synovial fluid. These changes may explain some of the mechanisms by which the articular symptoms are improved by filtration LCP.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0733-2459
pubmed:author
pubmed:copyrightInfo
Copyright 2001 Wiley-Liss, Inc.
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
74-81
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:11746532-Adult, pubmed-meshheading:11746532-Arthritis, Rheumatoid, pubmed-meshheading:11746532-Autoimmune Diseases, pubmed-meshheading:11746532-Chemokine CCL2, pubmed-meshheading:11746532-Chemokine CCL5, pubmed-meshheading:11746532-Cytokines, pubmed-meshheading:11746532-Double-Blind Method, pubmed-meshheading:11746532-Female, pubmed-meshheading:11746532-Filtration, pubmed-meshheading:11746532-Granulocyte-Macrophage Colony-Stimulating Factor, pubmed-meshheading:11746532-Humans, pubmed-meshheading:11746532-Interleukins, pubmed-meshheading:11746532-Leukapheresis, pubmed-meshheading:11746532-Macrophage Colony-Stimulating Factor, pubmed-meshheading:11746532-Male, pubmed-meshheading:11746532-Middle Aged, pubmed-meshheading:11746532-Synovial Fluid, pubmed-meshheading:11746532-Th1 Cells, pubmed-meshheading:11746532-Th2 Cells, pubmed-meshheading:11746532-Treatment Outcome, pubmed-meshheading:11746532-Tumor Necrosis Factor-alpha
pubmed:year
2001
pubmed:articleTitle
Dynamic changes in cytokine levels in serum and synovial fluid following filtration leukocytapheresis therapy in patients with rheumatoid arthritis.
pubmed:affiliation
Internal Medicine I, National Defense Medical College, Tokorozawa, Saitama, Japan.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Randomized Controlled Trial