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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5-6
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pubmed:dateCreated |
1975-12-20
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pubmed:abstractText |
Protein deficiency in post-suckling rats produced changes in the activity of hepatic drug-metabolizing enzymes. Significant decreases occurred in the N-demethylation of aminopyrine, in the azo-reduction of neoprontosil and in sulfokinase activity (using p-nitrophenylsulfate as SO4 donor). An increase was recorded for the glucuronidation of p-nitrophenol and no changes were noted in the hydroxylations of hexobarbital and aniline. Refeeding the animals for 3 weeks returned all activities to control values. An exception was the azo-reductase activity indicating either a slower recovery or a permanent change.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0006-3126
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
339-51
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pubmed:dateRevised |
2009-6-30
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pubmed:meshHeading |
pubmed-meshheading:1174605-Aminopyrine,
pubmed-meshheading:1174605-Aniline Compounds,
pubmed-meshheading:1174605-Animals,
pubmed-meshheading:1174605-Azo Compounds,
pubmed-meshheading:1174605-Biotransformation,
pubmed-meshheading:1174605-Cytochrome Reductases,
pubmed-meshheading:1174605-Cytochromes,
pubmed-meshheading:1174605-Hexobarbital,
pubmed-meshheading:1174605-Liver,
pubmed-meshheading:1174605-Male,
pubmed-meshheading:1174605-Nitrophenols,
pubmed-meshheading:1174605-Oxidation-Reduction,
pubmed-meshheading:1174605-Protein Deficiency,
pubmed-meshheading:1174605-Rats,
pubmed-meshheading:1174605-Sulfates
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pubmed:year |
1975
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pubmed:articleTitle |
Effect of weanling malnutrition upon hepatic drug metabolism.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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