Source:http://linkedlifedata.com/resource/pubmed/id/11745936
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2001-12-17
|
| pubmed:abstractText |
Adenovirus (Ad)-induced acute respiratory illnesses resurged among civilian adults and selected military training populations in the United States during the late 1990s. We examined the epidemiologic and immunologic correlates of Ad-induced respiratory illnesses during a large outbreak at an Army basic training installation in southeast United States during a 9-day period in November 1997. A total of 79 recruits hospitalized with acute respiratory illnesses were evaluated during the outbreak period; confirmation of Ad infection by isolation of Ad-like cytopathic agents from throat cultures was detected in 71 (90%) of these patients. Serotyping of 19 (27%) of these 71 isolates identified the etiologic agent to be Ad type 4 (Ad4). In addition, 30 (81%) of 37 patients in whom paired sera were collected demonstrated significant increases (i.e., 4-fold or higher) in serum anti-Ad4 neutralizing antibodies. Anti-Ad4 immunity in new recruits was found to be very low (15 to 22%). A case-control study involving 66 of the 79 hospitalized cases and 189 non-ill controls from the same units was conducted. A lower risk of hospitalization for acute respiratory illnesses was documented for female recruits (odds ratio[OR] = 0.47, P <.05) whereas, a higher risk was noted for smokers (OR = 1.89, P <.05). Unit (training company) attack rates as high as 8 to 10% per week were documented and the outbreak quickly subsided after live, oral Ad types 4 and 7 vaccination was resumed in November 1997. Re-establishment of a military Ad vaccination program is critical for control of Ad-induced acute respiratory illnesses.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0146-6615
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| pubmed:author |
pubmed-author:ANCAVV,
pubmed-author:ConollyJJ,
pubmed-author:CraigS CSC,
pubmed-author:InnisB LBL,
pubmed-author:KohlhaseK FKF,
pubmed-author:LeeTT,
pubmed-author:MarquesJ SJS,
pubmed-author:Mitchell-RaymundoFF,
pubmed-author:PolyakC SCS,
pubmed-author:ReynoldsR DRD,
pubmed-author:SanchezJ LJL,
pubmed-author:ShepherdG AGA
|
| pubmed:copyrightInfo |
Copyright 2001 Wiley-Liss, Inc.
|
| pubmed:issnType |
Print
|
| pubmed:volume |
65
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
710-8
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:11745936-Acute Disease,
pubmed-meshheading:11745936-Adenoviridae,
pubmed-meshheading:11745936-Adenoviridae Infections,
pubmed-meshheading:11745936-Adult,
pubmed-meshheading:11745936-Antibodies, Viral,
pubmed-meshheading:11745936-Case-Control Studies,
pubmed-meshheading:11745936-Disease Outbreaks,
pubmed-meshheading:11745936-Female,
pubmed-meshheading:11745936-Hospitalization,
pubmed-meshheading:11745936-Humans,
pubmed-meshheading:11745936-Male,
pubmed-meshheading:11745936-Military Personnel,
pubmed-meshheading:11745936-Neutralization Tests,
pubmed-meshheading:11745936-Respiratory Tract Infections,
pubmed-meshheading:11745936-Risk Factors,
pubmed-meshheading:11745936-Serotyping,
pubmed-meshheading:11745936-Smoking,
pubmed-meshheading:11745936-United States
|
| pubmed:year |
2001
|
| pubmed:articleTitle |
Epidemic of adenovirus-induced respiratory illness among US military recruits: epidemiologic and immunologic risk factors in healthy, young adults.
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| pubmed:affiliation |
Directorate of Epidemiology and Disease Surveillance and Clinical Preventive Medicine, US Army Center for Health Promotion and Preventive Medicine (USACHPPM), Aberdeen Proving Ground, Maryland, USA.
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| pubmed:publicationType |
Journal Article,
Comparative Study
|