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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1976-1-2
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pubmed:abstractText |
The synthesis of several N-(5'-phosphopyridoxyl)-amino acids is described. These compounds, analogs of the Schiff base intermediate involved in enzyme-catalyzed decarboxylation, are potent inhibitors of the cognate amino acid decarboxylases. Kinetic studies using partially purified rat liver ornithine decarboxylase, have shown that N-(5'-phosphopyridoxyl)-ornithine inhibits the enzyme in a non-competitive manner with respect to both ornithine and pyridoxal-5'-phosphate. These findings suggest that the inhibitor binds to the holoenzyme active site in place of the Schiff base intermediate.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0006-3002
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
22
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pubmed:volume |
403
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
197-207
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1174545-Animals,
pubmed-meshheading:1174545-Binding Sites,
pubmed-meshheading:1174545-Carboxy-Lyases,
pubmed-meshheading:1174545-Dexamethasone,
pubmed-meshheading:1174545-Enzyme Induction,
pubmed-meshheading:1174545-Kinetics,
pubmed-meshheading:1174545-Liver,
pubmed-meshheading:1174545-Ornithine,
pubmed-meshheading:1174545-Ornithine Decarboxylase,
pubmed-meshheading:1174545-Protein Binding,
pubmed-meshheading:1174545-Pyridoxal Phosphate,
pubmed-meshheading:1174545-Rats,
pubmed-meshheading:1174545-Schiff Bases
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pubmed:year |
1975
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pubmed:articleTitle |
Stable multisubstrate adducts as enzyme inhibitors. Potent inhibition of ornithine decarboxylase by N-(5'-phosphopyridoxyl)-ornithine.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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