Source:http://linkedlifedata.com/resource/pubmed/id/11745343
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
11
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pubmed:dateCreated |
2001-12-17
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pubmed:abstractText |
HER-2/neu is a tumor-associated antigen overexpressed in a large variety of human tumors. Eight HER-2/neu peptides displaying HLA-A*0201 anchoring motifs were selected and tested for their binding affinity to HLA-A*0201 and their capacity to elicit cytotoxic T lymphocyte (CTL) responses in both HLA-A*0201 transgenic mice and in HLA-A*0201(+) healthy donors. Two high-affinity (p5 and p48) and one intermediate-affinity (p1023) peptides triggered CTL responses in both transgenic mice and humans, comparable to those observed for the well-known HER2/neu dominant peptide p369. CTL induced in transgenic mice lysed HLA-A*0201(+) RMA cells infected with recombinant HER-2/neu but not cells infected with wild-type vaccinia virus. Human CTL lysed HLA-A*0201(+) HER-2/neu(+) tumor cells of different origins (breast, colon, lung and renal cancer) irrespective of the expression levels of HER-2/neu. Importantly, primed CTL specific for these epitopes were detected in freshly isolated tumor-infiltrating lymphocytes from three renal cell carcinoma patients. Therefore, the HER-2/neu peptides p5, p48 and p1023 may be good candidates for immunotherapy of a broad spectrum of tumors, including renal cell carcinoma.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0014-2980
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pubmed:author |
pubmed-author:AlvesPP,
pubmed-author:AngevinEE,
pubmed-author:CardosoA AAA,
pubmed-author:ChouaibSS,
pubmed-author:FiratHH,
pubmed-author:Graff-DuboisSS,
pubmed-author:GrossD ADA,
pubmed-author:KosmatopoulosKK,
pubmed-author:LemonnierFF,
pubmed-author:NadlerL MLM,
pubmed-author:ScardinoAA,
pubmed-author:TourdotSS
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pubmed:issnType |
Print
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3261-70
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11745343-Animals,
pubmed-meshheading:11745343-Carcinoma, Renal Cell,
pubmed-meshheading:11745343-Epitopes,
pubmed-meshheading:11745343-HLA-A Antigens,
pubmed-meshheading:11745343-Humans,
pubmed-meshheading:11745343-Immunotherapy,
pubmed-meshheading:11745343-Kidney Neoplasms,
pubmed-meshheading:11745343-Mice,
pubmed-meshheading:11745343-Receptor, erbB-2,
pubmed-meshheading:11745343-T-Lymphocytes, Cytotoxic
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pubmed:year |
2001
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pubmed:articleTitle |
Identification of HER-2/neu immunogenic epitopes presented by renal cell carcinoma and other human epithelial tumors.
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pubmed:affiliation |
INSERM 487, Institut Gustave Roussy, Villejuif, France.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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