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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2001-12-17
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pubmed:abstractText |
Activation of host phosphotyrosine phosphatase SHP-1 by Leishmania and its subsequent impact on tyrosine phosphorylation-based signaling cascades were shown to represent an important mechanism whereby this pathogen may alter host cell functions. Herein, we report that Leishmania-induced macrophage SHP-1 activity is necessary for its survival within phagocytes through the attenuation of nitric oxide-dependent and -independent microbicidal mechanisms. In vivo, Leishmania major infection, which footpad inflammation is mostly undetectable in SHP-1-deficient viable motheaten mice, was accompanied by increased inducible nitric oxide synthase and activation of neutrophils. These enhanced cellular activities were paralleled by a marked activation of signaling events usually negatively regulated by SHP-1. Overall, this study firmly establishes that modulation of the signaling terminator SHP-1 by Leishmania is essential for its installment and propagation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Chuk protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/I-kappa B Kinase,
http://linkedlifedata.com/resource/pubmed/chemical/Ikbkb protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Ikbke protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Tyrosine Phosphatase...,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Tyrosine Phosphatase...,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Tyrosine Phosphatases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Ptpn11 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Ptpn6 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0014-2980
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3185-96
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11745335-Animals,
pubmed-meshheading:11745335-Cell Line,
pubmed-meshheading:11745335-I-kappa B Kinase,
pubmed-meshheading:11745335-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:11745335-Leishmaniasis, Cutaneous,
pubmed-meshheading:11745335-Mice,
pubmed-meshheading:11745335-Mice, Inbred C3H,
pubmed-meshheading:11745335-Mice, Inbred C57BL,
pubmed-meshheading:11745335-Mitogen-Activated Protein Kinases,
pubmed-meshheading:11745335-NF-kappa B,
pubmed-meshheading:11745335-Neutrophils,
pubmed-meshheading:11745335-Nitric Oxide,
pubmed-meshheading:11745335-Protein Tyrosine Phosphatase, Non-Receptor Type 11,
pubmed-meshheading:11745335-Protein Tyrosine Phosphatase, Non-Receptor Type 6,
pubmed-meshheading:11745335-Protein Tyrosine Phosphatases,
pubmed-meshheading:11745335-Protein-Serine-Threonine Kinases,
pubmed-meshheading:11745335-RNA, Messenger
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pubmed:year |
2001
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pubmed:articleTitle |
Role of host phosphotyrosine phosphatase SHP-1 in the development of murine leishmaniasis.
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pubmed:affiliation |
Centre de Recherche en Infectiologie CHUQ, Université Laval, Ste-Foy, Québec, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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