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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2001-12-17
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pubmed:abstractText |
Two-thirds of patients with squamous cell carcinomas of the head and neck (SCCHN) at diagnosis have advanced disease with projected 5-year survival rates of 30%. In those patients with distant metastatic or previously treated recurrent disease, response rate to the standard regimen of cisplatin and 5-fluorouracil is approximately 30%. The authors investigated the use of paclitaxel and carboplatin in a limited Phase II study in recurrent or metastatic SCCHN to evaluate tumor response, time to progression, survival, and toxicities of this regimen.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0008-543X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2001 American Cancer Society.
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
92
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2334-40
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pubmed:dateRevised |
2006-4-24
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pubmed:meshHeading |
pubmed-meshheading:11745288-Adult,
pubmed-meshheading:11745288-Aged,
pubmed-meshheading:11745288-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:11745288-Carboplatin,
pubmed-meshheading:11745288-Carcinoma, Squamous Cell,
pubmed-meshheading:11745288-Disease Progression,
pubmed-meshheading:11745288-Female,
pubmed-meshheading:11745288-Granulocyte Colony-Stimulating Factor,
pubmed-meshheading:11745288-Head and Neck Neoplasms,
pubmed-meshheading:11745288-Humans,
pubmed-meshheading:11745288-Infusions, Intravenous,
pubmed-meshheading:11745288-Male,
pubmed-meshheading:11745288-Middle Aged,
pubmed-meshheading:11745288-Neoplasm Recurrence, Local,
pubmed-meshheading:11745288-Neutropenia,
pubmed-meshheading:11745288-Paclitaxel,
pubmed-meshheading:11745288-Survival Analysis,
pubmed-meshheading:11745288-Thrombocytopenia,
pubmed-meshheading:11745288-Treatment Outcome
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pubmed:year |
2001
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pubmed:articleTitle |
Phase II evaluation of paclitaxel in combination with carboplatin in advanced head and neck carcinoma.
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pubmed:affiliation |
Department of Medicine, Division of Hematology/Oncology, Loyola University Medical Center/Cardinal Bernardin Cancer Center, 2160 South First Avenue, Maywood, IL 60153, USA. jclark@lumc.edu
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Clinical Trial, Phase II
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