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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2001-12-17
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pubmed:abstractText |
We studied the roles of mGlu2/3 receptors (mGlu2/3) in glutamatergic transmission at corticostriatal synapses in mice brain slices. Perfusion of the selective mGlu2/3 agonists LY354740 and L-CCG1 caused the long term depression (LTD) of evoked synaptic responses. Photonic and electronic microscopy showed mGlu2/3 on axonal fibers and glial processes but not on striatal dendrites. mGlu2/3-LTD was independent of synaptic activity and insensitive to specific antagonists of dopamine D1, D2, GABA(B), N-methyl-D-aspartate or adenosine A1 receptors. Manipulation of the cAMP/protein kinase A cascade had no effect on the mGlu2/3-LTD. In contrast, MEK1-2 inhibitors reduced both mGlu2/3 initial depression and LTD suggesting the involvement of the mitogen activated kinase pathway in mGlu2/3-LTD.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP-Dependent Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Dopamine Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/GABA Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Glutamic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/MAP Kinase Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Map2k1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase...,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Metabotropic Glutamate,
http://linkedlifedata.com/resource/pubmed/chemical/metabotropic glutamate receptor 2
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0304-3940
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
28
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pubmed:volume |
316
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
178-82
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11744231-Adrenergic Antagonists,
pubmed-meshheading:11744231-Animals,
pubmed-meshheading:11744231-Cerebral Cortex,
pubmed-meshheading:11744231-Cyclic AMP-Dependent Protein Kinases,
pubmed-meshheading:11744231-Dendrites,
pubmed-meshheading:11744231-Dopamine Antagonists,
pubmed-meshheading:11744231-Excitatory Amino Acid Agonists,
pubmed-meshheading:11744231-Excitatory Amino Acid Antagonists,
pubmed-meshheading:11744231-Fluorescent Antibody Technique,
pubmed-meshheading:11744231-GABA Antagonists,
pubmed-meshheading:11744231-Glutamic Acid,
pubmed-meshheading:11744231-MAP Kinase Kinase 1,
pubmed-meshheading:11744231-Male,
pubmed-meshheading:11744231-Membrane Potentials,
pubmed-meshheading:11744231-Mice,
pubmed-meshheading:11744231-Mice, Inbred C57BL,
pubmed-meshheading:11744231-Microscopy, Electron,
pubmed-meshheading:11744231-Mitogen-Activated Protein Kinase Kinases,
pubmed-meshheading:11744231-Neostriatum,
pubmed-meshheading:11744231-Neural Inhibition,
pubmed-meshheading:11744231-Neural Pathways,
pubmed-meshheading:11744231-Neuroglia,
pubmed-meshheading:11744231-Neuronal Plasticity,
pubmed-meshheading:11744231-Presynaptic Terminals,
pubmed-meshheading:11744231-Protein-Serine-Threonine Kinases,
pubmed-meshheading:11744231-Receptors, Metabotropic Glutamate,
pubmed-meshheading:11744231-Synaptic Transmission
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pubmed:year |
2001
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pubmed:articleTitle |
Group 2 metabotropic glutamate receptors induced long term depression in mouse striatal slices.
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pubmed:affiliation |
CNRS UPR 9023, 141, Rue de la Cardonille, 34094 Montpellier Cedex 05, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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