Source:http://linkedlifedata.com/resource/pubmed/id/11743353
Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
|
pubmed:dateCreated |
2001-12-14
|
pubmed:abstractText |
Chemotherapy is often used as a primary therapy for metastatic cancer because it kills cells en masse. However, high doses of chemotherapeutic drugs can cause toxicity in nontarget organs. Gene therapy may provide a better alternative to chemotherapy because its targeting of specific genes may reduce the undesirable toxicity associated with chemotherapy. We evaluated whether the chemotherapeutic agent docetaxel or paclitaxel may be combined with gene therapy to create a new therapeutic regimen for metastatic androgen independent prostate cancer.
|
pubmed:grant | |
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
AIM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Jan
|
pubmed:issn |
0022-5347
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
167
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
339-46
|
pubmed:dateRevised |
2007-11-14
|
pubmed:meshHeading |
pubmed-meshheading:11743353-Adenoviridae,
pubmed-meshheading:11743353-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:11743353-Gene Expression,
pubmed-meshheading:11743353-Gene Therapy,
pubmed-meshheading:11743353-Humans,
pubmed-meshheading:11743353-Male,
pubmed-meshheading:11743353-Paclitaxel,
pubmed-meshheading:11743353-Prostatic Neoplasms,
pubmed-meshheading:11743353-Taxoids,
pubmed-meshheading:11743353-Transgenes,
pubmed-meshheading:11743353-Tumor Cells, Cultured
|
pubmed:year |
2002
|
pubmed:articleTitle |
Enhanced transgene expression in androgen independent prostate cancer gene therapy by taxane chemotherapeutic agents.
|
pubmed:affiliation |
Department of Urology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9110, USA.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|