Linked Life Data

11743228

Source:http://linkedlifedata.com/resource/pubmed/id/11743228

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2001-12-14
pubmed:abstractText
In vitro studies have shown that beta-blockers are taken up into and released from adrenergic cells together with epinephrine and norepinephrine. Consequently, studies in humans revealed an increase in plasma concentrations of propranolol and atenolol during physical exercise. However, carvedilol has not been investigated in a similar fashion. Eleven hypertensive patients on long-term treatment (4 months) with carvedilol followed an exercise regimen. Plasma concentrations of carvedilol were determined at rest (9.7 +/- 3.4 ng/ml), during exercise (9.0 +/- 3.2 ng/ml), and after 15 min of recovery (9.1 +/- 2.7 ng/ml). Contrary to predictions, exercise had no effect on plasma concentrations of carvedilol, a finding that is in contrast to other beta-blockers. We conclude that carvedilol is not taken up into and released from adrenergic nerves during exercise, a feature that clearly distinguishes carvedilol from all other beta-adrenergic antagonists so far investigated.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0160-2446
pubmed:author
pubmed:issnType
Print
pubmed:volume
39
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
58-60
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Unpredicted lack of effect of exercise on plasma concentrations of carvedilol.
pubmed:affiliation
Division of Cardiology, Department of Medicine, Karl Franzens University, Graz, Austria. kurt.stoschitzky@kfunigraz.ac.at
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't