Source:http://linkedlifedata.com/resource/pubmed/id/11742414
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6865
|
| pubmed:dateCreated |
2001-12-19
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| pubmed:abstractText |
Diabetes-specific microvascular disease is a leading cause of blindness, renal failure and nerve damage, and diabetes-accelerated atherosclerosis leads to increased risk of myocardial infarction, stroke and limb amputation. Four main molecular mechanisms have been implicated in glucose-mediated vascular damage. All seem to reflect a single hyperglycaemia-induced process of overproduction of superoxide by the mitochondrial electron-transport chain. This integrating paradigm provides a new conceptual framework for future research and drug discovery.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0028-0836
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
13
|
| pubmed:volume |
414
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
813-20
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11742414-Diabetes Complications,
pubmed-meshheading:11742414-Diabetes Mellitus,
pubmed-meshheading:11742414-Diabetic Angiopathies,
pubmed-meshheading:11742414-Forecasting,
pubmed-meshheading:11742414-Glycosylation End Products, Advanced,
pubmed-meshheading:11742414-Hexosamines,
pubmed-meshheading:11742414-Humans,
pubmed-meshheading:11742414-Hyperglycemia,
pubmed-meshheading:11742414-Protein Kinase C
|
| pubmed:year |
2001
|
| pubmed:articleTitle |
Biochemistry and molecular cell biology of diabetic complications.
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| pubmed:affiliation |
Department of Medicine, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York, 10461, USA. brownlee@aecom.yu.edu
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|