Linked Life Data

11742255

Source:http://linkedlifedata.com/resource/pubmed/id/11742255

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
18
pubmed:dateCreated
2001-12-19
pubmed:abstractText
Glucose-6-phosphate dehydrogenase (G6PD) purified from rabbit brain is composed of two identical subunits of 56 kDa. The enzyme exhibits biphasic pH curve, linear Arrhenius plot and elevated susceptibility to inactivation by metal catalyzed oxidation and thiol binding reagents. 4-Hydroxy-2-nonenal (HNE) is able to inactivate the enzyme after only a few minutes of incubation. Since reactive oxygen species and G6PD-HNE adducts form easily in brain under conditions of oxidative stress, these findings have important implications in the loss of active G6PD molecules in vivo, a process which lowers the antioxidant protection and may be critical for neuron survival.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0959-4965
pubmed:author
pubmed:issnType
Print
pubmed:day
21
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4149-53
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Rabbit brain glucose-6-phosphate dehydrogenase: biochemical properties and inactivation by free radicals and 4-hydroxy-2-nonenal.
pubmed:affiliation
Istituto di Chimica Biologica G. Fornaini, Via Saffi 2, 61029 Urbino (PU) Italy.
pubmed:publicationType
Journal Article, Comparative Study