Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
18
pubmed:dateCreated
2001-12-19
pubmed:abstractText
The present study explored the efficacy of leptin in protecting against in vivo induction of excitotoxic lesions by the glutamatergic analogue ibotenate injected into the developing mouse brain and against in vitro NMDA-induced cell death in primary neuronal cultures. Ibotenate injected intracerebrally (i.c.) to mice on postnatal day 5 produced transcortical necrosis and white matter cysts. Co-treatment with leptin administered i.c. or i.p. reduced ibotenate-induced cortical lesions and white matter cysts by 50%. in vitro, leptin afforded significant neuroprotection of mouse cortical neurons against NMDA cytotoxicity. The neuroprotective effect of leptin was antagonized both in vivo and in vitro by the Jak2 inhibitor AG490, indicating that it was mediated via the leptin receptor and Jak2 activation. These findings are the first evidence for a role of leptin in neuroprotection.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Agonists, http://linkedlifedata.com/resource/pubmed/chemical/Ibotenic Acid, http://linkedlifedata.com/resource/pubmed/chemical/Jak2 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Janus Kinase 2, http://linkedlifedata.com/resource/pubmed/chemical/Leptin, http://linkedlifedata.com/resource/pubmed/chemical/N-Methylaspartate, http://linkedlifedata.com/resource/pubmed/chemical/Neuroprotective Agents, http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Tyrphostins, http://linkedlifedata.com/resource/pubmed/chemical/alpha-cyano-(3,4-dihydroxy)-N-benzyl...
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0959-4965
pubmed:author
pubmed:issnType
Print
pubmed:day
21
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3947-51
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:11742217-Animals, pubmed-meshheading:11742217-Animals, Newborn, pubmed-meshheading:11742217-Cell Survival, pubmed-meshheading:11742217-Cells, Cultured, pubmed-meshheading:11742217-Cerebral Cortex, pubmed-meshheading:11742217-Enzyme Inhibitors, pubmed-meshheading:11742217-Excitatory Amino Acid Agonists, pubmed-meshheading:11742217-Female, pubmed-meshheading:11742217-Ibotenic Acid, pubmed-meshheading:11742217-Injections, Intraventricular, pubmed-meshheading:11742217-Janus Kinase 2, pubmed-meshheading:11742217-Leptin, pubmed-meshheading:11742217-Male, pubmed-meshheading:11742217-Mice, pubmed-meshheading:11742217-N-Methylaspartate, pubmed-meshheading:11742217-Neurons, pubmed-meshheading:11742217-Neuroprotective Agents, pubmed-meshheading:11742217-Protein-Tyrosine Kinases, pubmed-meshheading:11742217-Proto-Oncogene Proteins, pubmed-meshheading:11742217-Tyrphostins
pubmed:year
2001
pubmed:articleTitle
Neuroprotective effects of leptin in vivo and in vitro.
pubmed:affiliation
INSERM E9935, Hôpital Robert-Debré, 48 Bvd Sérurier, F-75019 Paris, France.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't